Cost-Effectiveness of Monitoring and Liver Cancer Surveillance among Patients with Inactive Chronic Hepatitis B

PONE-D-24-36839

Dear Dr. Toy,

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Isabelle Chemin, PhD

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

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Reviewer #1: Yes

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: I Don't Know

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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5. Review Comments to the Author

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Reviewer #1: From a clinical perspective, this is a very important and immediate study. Due to the long-term nature and complexity of HBV infection, the inconsistency of guidelines for the diagnosis and treatment of hepatitis B, the accessibility of therapeutic drugs and the inconsistency of screening strategies in various regions of the world, the current treatment and control of CHB infection is extremely unsatisfactory. The significance of this study was used Markov model to figue out calculate the costs, health impact and cost-effectiveness, which can provide some reference evidence for the current inconsistent guidelines for treatment and screening strategies.

Reviewer #2: The paper is well-written and well-structured, with a thorough and well-executed statistical analysis in all aspects. Additionally, the references to existing literature appear complete. Therefore, I recommend accepting the paper as it is.

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Reviewer #1: No

Reviewer #2: No

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