PONE-D-24-28190Analysis of associated malformations in adults with polysplenia syndrome on CTPLOS ONE

Dear Dr. liu,

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Gurinder Kumar, MD

Academic Editor

PLOS ONE

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

Reviewer #4: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: No

Reviewer #3: Yes

Reviewer #4: N/A

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3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

Reviewer #4: No

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

Reviewer #4: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: Rigorously written article by the authors. It is a retrospective series, however the rarity of the condition makes the article useful. Adding percentages of findings in tables would have added to the readability of the article.

Reviewer #2: Dear Author,

Greetingd to you for drafting a study on an important disorder such as the Polysplenia disorder.

I commend your efforts totally.

I request you to please go through these observations at my end.

1. You can shorten the running title as the main title and running title appear to be the same.

2. Keywords may be chosen a bit more appropriately, for example, you may use a keyword like malformations which may be used instead of 'adult' making it a bit more specific and catchy.

3. The sample size being 12, I request you to make a small change in your title if possible, you can call this as a 'pilot' study.

4. In financial disclosure section, you have disclosed that there was no funding prpvided for your study. Under the fundings head, you are mentioning certain project names. Can you please clarify it further on how the projects helped in your study funding? Was it based on collection of patients or something related?

5. In your objective, can you replace the word 'summarise' to 'analytically depict' so that it becomes more measurable and oriented to your study results.

6. If you can have some statistical tests suitaing this quantitative study wherein you can further supplement your results with statisical evidence, it would make your study stronger.

7. Were the examining radiologists blinded from the patients? Were the patients blinded from the examining radiologists? Were both blinded from each other? Were the examining radiologists aware that this sort of study may take place in future subject to their reporting?

You can go through these points and take your time to consider them as well.

Regards.

Reviewer #3: Thank you for providing me the opportunity to review this original article. This article presents an interesting and rare appearance of polysplenia and associated anomalies. A few corrections are required for further processing which have been described in the word file in the comment section.

Reviewer #4: With 12 cases, the topic should be better under a case review series rather than a research article.

Author/s should describe the spectrum of heterotaxy or situs ambiguus syndromes in a small paragraph in the discussion introduction.

The author/s should mention in a concise paragraph the need for symptomatic management in the patients, depending on the type of associated anomaly, along with the importance of frequent follow-up with a multidisciplinary team. 

Fig 1l Duodenal duodenum anterior portal vein (PDPV) - correct the terminology

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Reviewer #1: No

Reviewer #2: Yes: Gaurav Vedprakash Mishra

Reviewer #3: Yes: Anshul Sood

Reviewer #4: Yes: Dr Swati Goyal

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Attachments

Attachment

Submitted filename: PONE-D-24-28190_reviewer.docx

Analysis of associated malformations by computed tomography in adults with polysplenia syndrome: A Pilot Study

PONE-D-24-28190R1

Dear Dr. liu,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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If your institution or institutions have a press office, please notify them about your upcoming paper to help maximize its impact. If they’ll be preparing press materials, please inform our press team as soon as possible -- no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org.

Kind regards,

Gurinder Kumar, MD

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #2: All comments have been addressed

Reviewer #3: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #2: Yes

Reviewer #3: Yes

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3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #2: Yes

Reviewer #3: Yes

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4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #2: Yes

Reviewer #3: Yes

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5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #2: Yes

Reviewer #3: Yes

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6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #2: Dear authors, it is a nice effort by you to carry up this draft in such a manner.

my comments have been satisfactorily addressed.

Good luck to all of you.

Reviewer #3: The recommended changes have been incorporated in the manuscript.

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7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #2: Yes: Gaurav Vedprakash Mishra

Reviewer #3: Yes: Anshul Sood

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