PONE-D-24-07811Efficacy and safety of Moderate-intensity Rosuvastatin Plus Ezetimibe versus High-intensity Rosuvastatin Monotherapy in the treatment of Composite Cardiovascular Events with hypercholesterolemia: A Meta-analysisPLOS ONE

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Academic Editor

PLOS ONE

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

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3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: I have suggested only few grammatical mistakes that needs to be corrected over all very well written analysis on RCT comparing statin therapy and ezetimibe I do advise to correct the first opening sentence

Reviewer #2: This study addresses a critical gap in current clinical practice by systematically comparing the lipid-lowering efficacy and safety of moderate-intensity rosuvastatin combined with ezetimibe versus high-intensity rosuvastatin monotherapy. Through a rigorous meta-analysis of randomized controlled trials (RCTs), this research aims to inform and refine treatment strategies, enhancing patient outcomes and guiding clinicians in the optimal management of dyslipidemia.

I would propose minor points to be revised:

-Abstract

In the section of results, please replace in the first sentence comma with full stop.

-Introduction

First Paragraph:

Consider revising "considered the cornerstone of control of dyslipidemia or atherosclerotic cardiovascular disease (ASCVD)" to "considered the cornerstone in the control of dyslipidemia and atherosclerotic cardiovascular disease (ASCVD)".

Second Paragraph:

Revise "more studies at both domestic and international" to "more studies, both domestic and international".

Consider adding a comma after "improve the safety during treatment".

Third Paragraph:

Revise "Recently, Various randomized controlled trials" to "Recently, various randomized controlled trials".

-Results

Search Results:

Revise "280 full-text papers were rejected according to the inclusion and exclusion criterion" to "280 full-text papers were excluded based on the inclusion and exclusion criteria".

Study Characteristics and Quality Assessment:

Consider revising "The meta-analysis presented 21 RCTS" to "The meta-analysis included 21 RCTs".

-Discussion

First Paragraph:

Revise "twice as many adverse cardiovascular events as those with normal lipids" to "twice as many adverse cardiovascular events compared to those with normal lipids".

Second Paragraph:

Clarify "most national or regional lipid management guidelines recommend LDL-Cas the primary goal" by adding a space in "LDL-Cas" to "LDL-C as".

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Reviewer #1: Yes: Gurpreet Kaur Saini

Reviewer #2: No

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Attachments

Attachment

Submitted filename: PLOS one Efficacy and safety of Rosuvastatin with ezetimibe .pdf

Efficacy and safety of moderate-intensity rosuvastatin plus ezetimibe versus high-intensity rosuvastatin monotherapy in the treatment of composite cardiovascular events with hypercholesterolemia: A meta-analysis

PONE-D-24-07811R1

Dear Dr. liu,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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Kind regards,

Jaspinder Kaur, MD

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #2: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #2: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #2: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #2: Yes

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5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #2: Yes

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #2: All comments were answered one by one in the revised form of manuscript by indicating the exact line.

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7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #2: No

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