PONE-D-23-28579Improved Pore Structure Characterization and Classification of Strong Diagenesis Sandstones by Data-mining Analytics in Tazhong Area, Tarim Basin

PLOS ONE

Dear Dr. Wang,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

Besides considering all the comments by the reviewers, I advise to pay close attention to the following topics:

• Please separated methodology and results. On the other hand, analysis, testing methods and quantities can be combined in a single section.
• Please optimize the Tables and Figures of the manuscript.
• Please add a more detailed description of the new findings and significance of the paper. This may require additional references to better situate the reader with respect to the state-of-the-art.

Please submit your revised manuscript by Jan 01 2024 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

Please include the following items when submitting your revised manuscript:

• A rebuttal letter that responds to each point raised by the academic editor and reviewer(s). You should upload this letter as a separate file labeled 'Response to Reviewers'.
• A marked-up copy of your manuscript that highlights changes made to the original version. You should upload this as a separate file labeled 'Revised Manuscript with Track Changes'.
• An unmarked version of your revised paper without tracked changes. You should upload this as a separate file labeled 'Manuscript'.

If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter.

If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: https://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols. Additionally, PLOS ONE offers an option for publishing peer-reviewed Lab Protocol articles, which describe protocols hosted on protocols.io. Read more information on sharing protocols at https://plos.org/protocols?utm_medium=editorial-email&utm_source=authorletters&utm_campaign=protocols.

We look forward to receiving your revised manuscript.

Kind regards,

Luan Carlos de Sena Monteiro Ozelim, D.Sc.

Academic Editor

PLOS ONE

Journal Requirements:

1. When submitting your revision, we need you to address these additional requirements.

Please ensure that your manuscript meets PLOS ONE's style requirements, including those for file naming. The PLOS ONE style templates can be found at 

https://journals.plos.org/plosone/s/file?id=wjVg/PLOSOne_formatting_sample_main_body.pdf and 

https://journals.plos.org/plosone/s/file?id=ba62/PLOSOne_formatting_sample_title_authors_affiliations.pdf

2. Did you know that depositing data in a repository is associated with up to a 25% citation advantage (https://doi.org/10.1371/journal.pone.0230416)? If you’ve not already done so, consider depositing your raw data in a repository to ensure your work is read, appreciated and cited by the largest possible audience. You’ll also earn an Accessible Data icon on your published paper if you deposit your data in any participating repository.

3. Please note that PLOS ONE has specific guidelines on code sharing for submissions in which author-generated code underpins the findings in the manuscript. In these cases, all author-generated code must be made available without restrictions upon publication of the work. Please review our guidelines at https://journals.plos.org/plosone/s/materials-and-software-sharing#loc-sharing-code and ensure that your code is shared in a way that follows best practice and facilitates reproducibility and reuse.

4. Thank you for stating the following financial disclosure: 

Tianchi talent project (Grant No.40300-23005104)

Please state what role the funders took in the study.  If the funders had no role, please state: "The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript." 

If this statement is not correct you must amend it as needed. 

Please include this amended Role of Funder statement in your cover letter; we will change the online submission form on your behalf.

5. Thank you for stating the following in the Acknowledgments Section of your manuscript: 

I am thankful to Meiling Zhang reviewing for comments and improvement to this manuscript. Comments from others reviewers, Berdan and Seuhan is acknowledged. This research is jointly funded by Tianchi project (Grant No.ZD2019-183-006).

We note that you have provided funding information that is not currently declared in your Funding Statement. However, funding information should not appear in the Acknowledgments section or other areas of your manuscript. We will only publish funding information present in the Funding Statement section of the online submission form. 

Please remove any funding-related text from the manuscript and let us know how you would like to update your Funding Statement. Currently, your Funding Statement reads as follows: 

Tianchi talent project (Grant No.40300-23005104)

Please include your amended statements within your cover letter; we will change the online submission form on your behalf.

6. In your Data Availability statement, you have not specified where the minimal data set underlying the results described in your manuscript can be found. PLOS defines a study's minimal data set as the underlying data used to reach the conclusions drawn in the manuscript and any additional data required to replicate the reported study findings in their entirety. All PLOS journals require that the minimal data set be made fully available. For more information about our data policy, please see http://journals.plos.org/plosone/s/data-availability.

Upon re-submitting your revised manuscript, please upload your study’s minimal underlying data set as either Supporting Information files or to a stable, public repository and include the relevant URLs, DOIs, or accession numbers within your revised cover letter. For a list of acceptable repositories, please see http://journals.plos.org/plosone/s/data-availability#loc-recommended-repositories. Any potentially identifying patient information must be fully anonymized.

Important: If there are ethical or legal restrictions to sharing your data publicly, please explain these restrictions in detail. Please see our guidelines for more information on what we consider unacceptable restrictions to publicly sharing data: http://journals.plos.org/plosone/s/data-availability#loc-unacceptable-data-access-restrictions. Note that it is not acceptable for the authors to be the sole named individuals responsible for ensuring data access.

We will update your Data Availability statement to reflect the information you provide in your cover letter.

Additional Editor Comments:

Dear Authors,

After careful analysis by two experts, to further proceed with the publication of the paper, a Major Review is required.

Besides considering all the comments by the reviewers, I advise to pay close attention to the following topics:

- Please separated methodology and results. On the other hand, analysis, testing methods and quantities can be combined in a single section.

- Please optimize the Tables and Figures of the manuscript.

- Please add a more detailed description of the new findings and significance of the paper. This may require additional references to better situate the reader with respect to the state-of-the-art.

[Note: HTML markup is below. Please do not edit.]

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

**********

2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

**********

3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

**********

4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

**********

5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: The manuscript is about the pore structure characteristics of sandstones in Tazhong area.

The text provides some new insights. However, this manuscript cannot be accepted in present state, unless the following issues and mistakes are modified. Major revision recommended.

1. Petrology characteristics of sandstone should be moved to the results part, it is your own research results, right? And the sample number of sandstone should be added in Fig.2 and Fig.3.

2. A and B of Fig, 3 did not include Folk (1973) sandstone classification, what’s the figure caption of c and d, which should include sample data, depth, PPL or XPL or CL.

3. Line 84, X-ray diffraction mentioned, where is your XRD data?

4. The author combined the methodology and results together, it is confusing. The analysis and testing methods and quantities should be put together.

5. The whole manuscript is actually based on the classification of sandstones using thin sections and mercury intrusion, but I donot understand the roles of ‘strong diagenesis’ in it, what’s impact of strong diagenesis on the formation of sandstone.

6. What is MICP? I did not see the full name of it in the text.

7. What is the function of cathode luminescence in the pore structure classification?

Reviewer #2: The manuscript attempts to establish a framework for pore structure characterization and classification of strong diagenesis sandstones, combined with data analysis methods. Overall, this paper has certain innovation and practical significance.

The following comments and suggestions should guide the authors to better revise the paper:

1.The abstract of the manuscript is very detailed. However, sometimes such abstract cannot clearly reflect the key insights and particularities of the research. Therefore, it is suggested that the authors optimize the structure of the abstract to make it more concise.

2.References should be supplemented with the latest research results. The introduction section lacks support of recent years. It is suggested that authors update references. Due to the lack of support from relevant references, it is impossible to determine whether the author has tracked the latest progress, which may lead to problems in summarizing the current situation and sorting out the problems. It is very important for readers to understand the research background.

3.The text in Figure 1 should be in Times New Roman font. This Figure can be further optimized. The scale in Figure 3 cannot be seen clearly. Part of the text in Figure 6 is too small to read. Fig.8 is not clear, and the content cannot be seen clearly. Some text sizes in Figure 10 exceed the main text. They're lacks of explaining the Figure 11. please describe more.

4.Tables 2 and 5 have inserted figures in the table. Perhaps it would be more appropriate to directly modify it to a highly summarized figure. The authors can consider whether modifications are needed (this is only a suggestion)

5.Please further revise the statements in the paper that are difficult to read. Especially the naming of some new classifications. Part of the paper's discussion is not very user-friendly to readers and can be further optimized for expression. Commonly the abbreviations are explained the first time of the appearance of the corresponding terms. Here the abbreviations MICP, PCA, LDA, appearing in abstract, should be attributed to specific terms.

6.Please add more description of the new findings and significance of research. Especially in the abstract and conclusion section.

**********

6. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: No

Reviewer #2: No

**********

[NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files.]

While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool, https://pacev2.apexcovantage.com/. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email PLOS at figures@plos.org. Please note that Supporting Information files do not need this step.

PONE-D-23-28579R1Improved Pore Structure Characterization and Classification of Strong Diagenesis Sandstones by Data-mining Analytics in Tazhong Area, Tarim BasinPLOS ONE

Dear Dr. Wang,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

After another round of reviews, there are still some issues which must be addressed prior to the paper acceptance. In particular, the following issues need to be considered:

a) There is an apparent confusion about MICP results and their use in the paper. The authors indicate they were not suitable but apparently use it anyway. Please clarify;

b) The petrology characteristics of sandstone should be better described;

c) The results should be discussed in some detail;

d) There are problems with the formatting of the manuscript and with the English level. Please revise all of these before resubmitting.

Please submit your revised manuscript by Jun 08 2024 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

Please include the following items when submitting your revised manuscript:

• A rebuttal letter that responds to each point raised by the academic editor and reviewer(s). You should upload this letter as a separate file labeled 'Response to Reviewers'.
• A marked-up copy of your manuscript that highlights changes made to the original version. You should upload this as a separate file labeled 'Revised Manuscript with Track Changes'.
• An unmarked version of your revised paper without tracked changes. You should upload this as a separate file labeled 'Manuscript'.

If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter.

If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: https://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols. Additionally, PLOS ONE offers an option for publishing peer-reviewed Lab Protocol articles, which describe protocols hosted on protocols.io. Read more information on sharing protocols at https://plos.org/protocols?utm_medium=editorial-email&utm_source=authorletters&utm_campaign=protocols.

We look forward to receiving your revised manuscript.

Kind regards,

Luan Carlos de Sena Monteiro Ozelim, D.Sc.

Academic Editor

PLOS ONE

Additional Editor Comments:

Dear authors, after another round of reviews, there are still some issues which must be addressed prior to the paper acceptance. In particular, the following issues need to be considered:

a) There is an apparent confusion about MICP results and their use in the paper. The authors indicate they were not suitable but apparently use it anyway. Please clarify;

b) The petrology characteristics of sandstone should be better described;

c) The results should be discussed in some detail;

d) There are problems with the formatting of the manuscript and with the English level. Please revise all of these before resubmitting.

[Note: HTML markup is below. Please do not edit.]

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #3: All comments have been addressed

Reviewer #4: All comments have been addressed

**********

2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #3: Partly

Reviewer #4: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #3: Yes

Reviewer #4: No

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #3: No

Reviewer #4: Yes

**********

5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #3: Yes

Reviewer #4: No

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #3: Dear Editor and authors

After Greetings,

Please find here in my comments on the manuscript number PONE-D-23-28579_R1.

This manuscript is well organized and easy to follow. It investigated an interesting research topic relevant to characterization and classification of pore structure in tight sandstone reservoirs. The topic fits well with the journal interest and it is of importance in tight sandstone reservoir. Authors attempted to provide pertinent details throughout the manuscript. However, I have some problems with the presentation and the arguments. The comments and suggestions are as follows:

1. Introduction: Author should introduce some new research trend on the characterization and classification of pore structure in tight sandstone reservoirs. Besides, it is necessary to clarify the importance of pore structure in tight sandstone.

2. Geological setting. Author should add some details and caption on each picture in the Fig.1 Where is the TZ11 and TZ12?

3. Geological setting. Line 65 what is “It” mean?

4. Geological setting. Line 65-68. The lithological characteristics of Jurassic system should be clarified carefully in the text.

5. Geological setting. Line 68-line 70 : Some references are needed to support the sedimentary facies.

4. Methodology

Author should explain the experimental analysis (e.g. MICP) or the source of experimental data.

5. Petrology characteristics of sandstone. This part is too simple and confusing. There is no caption and annotation in the Fig.5. The petrology characteristics of sandstone may be different in different Formation or member.

6. There is no discussion part in the manuscript. The structure of the manuscript need to be reorganized.

7. There are many language issues in the manuscript. The level of English of your manuscript does not meet the international journal's standard.

Reviewer #4: After carefully reading this article, there are some questions and suggestions regarding this article, as follows:

1. The use of “The Silurian system” ‘and “Sedimentation-diagenesis controls” as keywords in this article is inappropriate. It is recommended that the author readjust the keywords of this article;

2. In line 39, the author mentioned that analyzing MICP data does not reflect the real pore type, but the classification of pore structure in this article is based on MICP data. Does the MICP data analysis used in the article specifically adopt certain changes?

3. In lines 42-44, the shortcomings of nuclear magnetic technology and CT imaging techniques are mentioned, but the author's expression is not clear.

4. The list of nomenclature in line 61, since the full names and their corresponding abbreviations have already been mentioned earlier, there is no need to place them separately in the table;

5. The Pd, Smin, and Rd in the text should be written as Pd, Smin, and Rd, expressed using subscripts; Mpa should be written as MPa, and many physical quantities mentioned in the text have obvious errors in their units;

6. In lines 107-108, it is mentioned that " It can be classified into four rock types ", but why are there five types of rocks in Figures 4 (a) and (b)? What components do Q, F, and R represent in Figure 5? Suggest providing an explanation;

7. Placing XRD data in the reference list in lines 113-120 is deemed inappropriate, and it is recommended that the author revise it;

8. In Figure 8, the width of each column in the bar chart is different, and it is recommended to set it to a uniform width;

9. The use of references in this article is not standardized. The connected references in lines 41 and 42 should be placed in the same parentheses, and the same issue occurs in line 78; Lines 338-340 introduce the author's work and there is no need to add references;

10. The analysis and conclusion section of this article does not highlight the importance and innovation of the work done in the article;

11. The language of this article should be polished to improve its readability. And one more thing, is Wulumuqi in the address of the corresponding author the right English name of the city? And the second address is not complete.

**********

7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #3: No

Reviewer #4: No

**********

[NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files.]

While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool, https://pacev2.apexcovantage.com/. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email PLOS at figures@plos.org. Please note that Supporting Information files do not need this step.

Improved Pore Structure Characterization and Classification of Strong Diagenesis Sandstones by Data-mining Analytics in Tazhong Area, Tarim Basin

PONE-D-23-28579R2

Dear Dr. Wang,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

An invoice will be generated when your article is formally accepted. Please note, if your institution has a publishing partnership with PLOS and your article meets the relevant criteria, all or part of your publication costs will be covered. Please make sure your user information is up-to-date by logging into Editorial Manager at Editorial Manager® and clicking the ‘Update My Information' link at the top of the page. If you have any questions relating to publication charges, please contact our Author Billing department directly at authorbilling@plos.org.

If your institution or institutions have a press office, please notify them about your upcoming paper to help maximize its impact. If they’ll be preparing press materials, please inform our press team as soon as possible -- no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org.

Kind regards,

Luan Carlos de Sena Monteiro Ozelim, D.Sc.

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #3: All comments have been addressed

Reviewer #4: All comments have been addressed

**********

2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #3: Yes

Reviewer #4: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #3: Yes

Reviewer #4: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #3: Yes

Reviewer #4: Yes

**********

5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #3: Yes

Reviewer #4: Yes

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #3: This manuscript can be accepted in present state. However, there is no caption and annotation in the Fig.5

Reviewer #4: After reading the author's revised manuscript, I have noticed that the author has seriously considered and made corresponding revisions to the issues and suggestions raised before. These revisions have improved the quality of the paper to some extent. Based on the current content and quality, I believe that this paper has met the basic requirements for publication. Therefore, I agree with the publication of this paper.

**********

7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #3: No

Reviewer #4: No

**********