PONE-D-24-23292Association between nocturia and serum albumin in the U.S. adults from NHANES 2005-2012PLOS ONE

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Line 117–120 State that participants were screened for nocturia using a structured questionnaire. The inquiry posed was, "During the past 30 days, how many times per night did you most typically get up to urinate from the time going to bed at night to waking up in the morning?"

It is not clear whether the first urine passed on waking up was included or excluded from making the diagnosis of nocturia. There is a need to clarify this.

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Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: I Don't Know

Reviewer #3: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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Reviewer #1: Figure 2 Relationship between nocturia and albumin in Model 3. Mention it paragraph.

Abbreviation in abstract without clarify. Rewrite them with journal style.

References rewrite them with journal style too.

Reviewer #2: The subject has been previously investigated but the sample size and cosidering many factors that might affect nocturia makes the approach a novel one. The clinical impact of the study is not clear for me and its influence on patients management is not fully understood but it opens the door for further studies.

Line 66 refernce 2: the refernce shows only correlation with th QOL and not motality.

Line 67 I suggest using complain or presentation rather than symptom which was repeated in the next line.

Line 86 reference 14; The patients with OAB have significantly lower SHIM score, testosterone level, and serum albumin level, have more proportion of severe ED. Lower not higher.

Line 201 do you mean exclusion criteria?

Line 370 I think good is more appropriate than excellent

Reviewer #3: The manuscript being presented in its current format is acceptable for publication in the journal PLOS ONE.

The findings of the study and the thorough explanation of this particular topic is adequate.

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Reviewer #1: Yes: Abudea Y. A. A.

Reviewer #2: Yes: Aly A. Abdel-Rahim

Reviewer #3: No

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Association between nocturia and serum albumin in the U.S. adults from NHANES 2005-2012

PONE-D-24-23292R1

Dear Dr. ,Huimin Long

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Kind regards,

Innocent Ijezie Chukwuonye, MBBS, FMCP (Internal Medicine)

Academic Editor

PLOS ONE