PONE-D-24-28656Determinants of glycemic control among persons living with type 2 diabetes mellitus attending a district hospital in GhanaPLOS ONE

Dear Dr. ADJEI,

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Seth Agyei Domfeh, PhD

Academic Editor

PLOS ONE

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Reviewer #1: Yes

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: The the manuscript the authors determines the level of glycemic control and the associated individual factors among type 2 diabetes mellitus (T2DM) patients attending a district hospital.

The authors clearly describes their methods and used appropiate statistical analysis for their data. The manuscript is well written and coherrent. The conclusion reached is supported by the analysis performed.

Reviewer #2: REVIEW COMMENTS FOR MANUSCRIPT PONE-D-24-28656

General Comments

Title and Abstract: The title accurately reflects the content of the study. The abstract is well-written, providing a concise summary of the study's objectives, methods, results, and conclusion. However, consider adding more details about the statistical methods in the abstract for clarity.

Introduction: The introduction provides a good background on the global and local burden of diabetes mellitus. The rationale for the study is clearly articulated, and the objectives are well-defined. However, the introduction could benefit from more recent references to strengthen the context of the study.

Methods: The methods section is detailed and appropriate for the research question. The study design, sampling method, and data collection procedures are well-explained. The statistical analysis methods are appropriate, but the handling of potential confounders should be described in more detail.

Results: The results are clearly presented with appropriate use of tables and figures. However, some results are repeated in the text that are already shown in tables, which may be unnecessary. Consider summarizing key points in the text and referring to the tables for detailed results.

Discussion: The discussion appropriately interprets the results in the context of existing literature. The implications of the findings are well-discussed, but the discussion of the study's limitations could be expanded, especially regarding the potential biases in self-reported data and the cross-sectional nature of the study.

Conclusion: The conclusion is concise and highlights the key findings of the study. It appropriately emphasizes the need for improved dietary management among T2DM patients.

References: The references are generally well-chosen and relevant. However, some references are relatively old, and the inclusion of more recent studies could enhance the discussion.

Specific Comments

Clarity and Readability: Some sentences are complex and could be simplified for better readability. For example, the sentence "The cornerstone of diabetes management is glycemic control, a complex process with different contributing factors" could be simplified to "Glycemic control is central to diabetes management, but it is influenced by various factors."

Consistency in Terminology: Ensure that terms such as "glycemic control" and "T2DM" are used consistently throughout the manuscript. For instance, "glycemic control" is sometimes referred to as "blood glucose control" or "HbA1c levels," which could confuse readers.

Statistical Analysis: The choice of statistical tests is appropriate, but the manuscript could benefit from a more detailed explanation of the multivariate logistic regression model, particularly how variables were selected for inclusion in the model.

Figures and Tables: Ensure that all figures and tables are clearly labeled and referenced in the text. Some tables may benefit from additional footnotes explaining abbreviations or providing context.

Limitations: The limitations section is brief and could be expanded to discuss the potential impact of selection bias, the accuracy of self-reported data, and other factors that may have influenced the study's findings.

Recommendations for Improvement

�Expand the literature review to include more recent studies that provide context for the findings.

�Simplify complex sentences to improve readability and ensure that the manuscript is accessible to a broad audience.

�Provide a more detailed explanation of the statistical methods, particularly the logistic regression analysis, to clarify how the results were derived.

�Enhance the discussion of limitations to provide a more balanced interpretation of the study's findings.

�Ensure all tables and figures are properly labeled and referenced in the text, with clear explanations provided where necessary.

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Reviewer #1: No

Reviewer #2: Yes: Kofi Boamah Mensah

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Determinants of glycemic control among persons living with type 2 diabetes mellitus attending a district hospital in Ghana

PONE-D-24-28656R1

Dear Dr. ADJEI,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

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Kind regards,

Seth Agyei Domfeh, PhD

Academic Editor

PLOS ONE