PONE-D-24-15043Global burden and epidemiological prediction of polycystic ovary syndrome from 1990 to 2019: a systematic analysis from the Global Burden of Disease Study 2019PLOS ONE

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Academic Editor

PLOS ONE

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: No

Reviewer #3: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: The manuscript is well-organized, presenting the research findings in a clear and understandable manner. The language used throughout is articulate and clear of any discernible spelling or grammatical errors. The conclusion drawn by the authors is both reasonable and well-supported by the comprehensive data provided.

Reviewer #2: Dear authors,

Thank you for submitting your work based on the Global Burden of Disease (2019) about the assessment of global, regional and national burden of PCOS in terms of incidence, prevalence, and years lived with disability (DLYs).

PCOS is a widespread disease affecting women during their reproductive years and beyond with its metabolic and oncological complications. It is an important health problem that should be addressed and concrete strategies drawn up.

I thank the authors for this article which could benefit the current efforts made globally, regionally, and nationally in order to advance PCOS management.

The manuscript is technically sound, and the methods permitted a thorough statistical analysis of the data.

However, I have few observations:

1. In the method section the correlation coefficient used was not mentioned.

2. The manuscript could benefit from editing. It must be clearer, with no ambiguity, which was the case for many sentences in the result sections.

148: There was an increase of 32 million PCOS patients worldwide…

149: The incidence of PCOS in one year increased from 1.4 million in 1990 to 2.1 million in 2019.

152: the region which had the highest incidence in 1990 ……..was the western pacific…..

154: this sentence should be rephrased so that we know that EAPC of incidence estimates of the Americas region was only one that decreased.

160: ASR were the highest in Region of the Americas in 1990 and 2019, while the EAPC estimates were highest in South-East Asia Region.

3. The legends in all the figures were illegible, so it was impossible to read them.

Thank you for your work.

Reviewer #3: This paper is, somehow, an interesting excercise of probabilistic (Bayesian) approaches to a previously collected data (from the Global Health data Exchange) . It is, as a hole, a very neat metodological excercise. From the clinical point of view, as it should be expected, it does not add any important data.

Methodologically, it is a very well designed analysis and allows to withdraw some info which, considering the heterogenicity of the sample and the variety of criteria involved, renders results that should be taken precauciously.

From the stylistic point of view, there are several abbreviations in the abstract that are totally inintelligible unless you read the entire paper (ASIR,HDI,ASIR and ASPIR). Those should be, either, properly adressed or retired.

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Reviewer #1: Yes: Lara Abu-Qutaish

Reviewer #2: No

Reviewer #3: Yes: Juan Carlos Bello Munoz

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Global burden and epidemiological prediction of polycystic ovary syndrome from 1990 to 2019: a systematic analysis from the Global Burden of Disease Study 2019

PONE-D-24-15043R1

Dear Dr. Yang Ye,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

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Kind regards,

Zhaoqing Du, Ph.D

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #2: All comments have been addressed

Reviewer #3: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #2: Yes

Reviewer #3: Yes

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3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #2: Yes

Reviewer #3: Yes

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4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #2: Yes

Reviewer #3: Yes

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5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #2: Yes

Reviewer #3: Yes

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6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #2: (No Response)

Reviewer #3: After thorough reading, I see no drawbacks for this version of the paper. All the suggested adjustments have been made

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7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #2: No

Reviewer #3: Yes: Juan Carlos BELLO MUÑOZ

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