PONE-D-24-09941Evaluation of Wound Healing and Anti-Inflammatory Activity of Hydro-alcoholic Extract and Solvent Fractions of the Leaves of Clerodendrum myricoides (Lamiaceae) in MicePLOS ONE

Dear Dr. Beyna,

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Ahmed E. Abdel Moneim

Academic Editor

PLOS ONE

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: No

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: The paper is well organized, well written and ready for direct publication by the journal from my point of view. The flow of thoughts and language are in the optimum level and professional enough for direct consideration as an exceptional article. The author wrote the literature successfully. The conclusion is compatible with results. My recommendation is to "accept" this article

Reviewer #2: Check the bibliographic entries throughout the text, some of which are non-compliant, review some entries in the bibliographic references

lack of The chemical test performed only revealed the qualitative and quantitative assessment of the different extracts, which is not sufficient to justify the motive for selecting different solvent fractions of the test extract. More over, all the different fractions need quantitative assessment of some potential bioactives, like total polyphenolic and flavonoid content determination.

Time or seasonality of plant material collection should be added.

Role medicinal plants should be discussed in the case of drug-resistant bacteria.

Check the bibliographic entries throughout the text, some of which are non-compliant, review some entries in the bibliographic references. some references are too old

Reviewer #3: The manuscript entitled “Evaluation of Wound Healing and Anti-Inflammatory Activity of Hydro-alcoholic Extract and Solvent Fractions of the Leaves of Clerodendrum myricoides (Lamiaceae) in Mice”, introduces new findings but requires significant revisions that undermine its originality.

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6. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: Yes: Tafere MULAW Belete

Reviewer #2: Yes: Teklie Mengie Ayele

Reviewer #3: No

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Attachments

Attachment

Submitted filename: Review comments and suggestions for authors.pdf

Evaluation of Wound Healing and Anti-Inflammatory Activity of Hydro-alcoholic Extract and Solvent Fractions of the Leaves of Clerodendrum myricoides (Lamiaceae) in Mice

PONE-D-24-09941R1

Dear Dr. Beyna,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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If your institution or institutions have a press office, please notify them about your upcoming paper to help maximize its impact. If they’ll be preparing press materials, please inform our press team as soon as possible -- no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org.

Kind regards,

Ahmed E. Abdel Moneim

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

Reviewer #2: All comments have been addressed

Reviewer #3: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: I appreciate the changes in the manuscript that is well adressed the reviewer comment and the article is well written acceptable for piblication.

Reviewer #2: (No Response)

Reviewer #3: The authors made all data underlying the findings in their manuscript fully available and the manuscript presented in an intelligible fashion and written in standard English. The authors have been answered all the questions in a proper way and that all responses meet formatting specifications.

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7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: Yes: Tafere Mulaw Belete

Reviewer #2: Yes: Teklie Mengie Ayele

Reviewer #3: No

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