PONE-D-24-11869Efficacy and Safety of Upadacitinib in the Treatment of Moderate-to-Severe Atopic Dermatitis: A Systematic ReviewPLOS ONE

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Reviewers' comments:

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Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: N/A

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Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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5. Review Comments to the Author

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Reviewer #1: Good comprehensive article

My suggestion is to add frequency of adverse events .

Frequency of cancers and thrombotic events has been mentioned, please add frequency of more common side effects like headache and nasopharyngitis.

Reviewer #2: To mention in detail regarding the efficacy of upadacitinib with respect to variations in ethnicity. Is it equally effective in all races? If not how does it differ? Any difference in onset of getting a therapeutic response/ duration of treatment/ side effects?

Reviewer #3: Thank you for your work; the interest in using Upadacitinib is increasing to treat refractory and unrespondant atopic dermatitis to the (classical) therapeutic option. However, the safety profile is a crucial concern. This manuscript will provide an additional overview of using this medication.

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Reviewer #1: No

Reviewer #2: No

Reviewer #3: No

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Attachments

Attachment

Submitted filename: review.docx

Efficacy and safety of upadacitinib in the treatment of moderate-to-severe atopic dermatitis: A systematic review

PONE-D-24-11869R1

Dear Dr. Tang,

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Kind regards,

Feroze Kaliyadan, M.D.

Academic Editor

PLOS ONE