PONE-D-24-03102Cutoff CT value can identify upper gastrointestinal bleeding on postmortem CT: development and validation studyPLOS ONE

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Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: I Don't Know

Reviewer #2: Yes

Reviewer #3: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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5. Review Comments to the Author

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Reviewer #1: Authors are using the terms CT and HU very frequently [for example, “mean CT value of the upper gastrointestinal contents was 48.2 Hounsfield units (HU)”]. Since this paper is going to be read by forensic people, who are not generally trained in radiology, the authors must explain these two concepts in simple terms. Rest of the paper appears okay to me.

Reviewer #2: In total a very informative and practically significant article.

Statistical tests are ok, the charts and the figures are adequate.

Data collection method was ok, however, it is mentioned (line no. 19, 56) that it is retrospective case control study and at line No. 58-60 it is mentioned that “Written informed consent for the use of cadavers in our study was obtained from all families of the deceased participants” needs explanation.

Reviewer #3: The article is a good research work in the field of Virtual Autopsy. This will help in upcoming centers of Virtual Autopsy for a more confirmatory diagnosis of Upper GI bleeding. The cutoff values mentioned will add to Medical literature.

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Reviewer #1: No

Reviewer #2: Yes: Amar Jyoti Patowary, Professor & Head, Deptt. of Forensic Medicine, NEIGRIHMS, Shillong, India

Reviewer #3: No

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Attachments

Attachment

Submitted filename: Reviewer comment.pdf

Cutoff CT value can identify upper gastrointestinal bleeding on postmortem CT: development and validation study

PONE-D-24-03102R1

Dear Dr. WATARU GONOI,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

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Kind regards,

Abhishek Das, MD

Academic Editor

PLOS ONE

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