Study Protocol for ADHERE (Applying Directly observed therapy to HydroxyurEa to Realize Effectiveness): Using small business partnerships to deliver a scalable and novel hydroxyurea adherence solution to youth with sickle cell disease

PONE-D-24-09379

Dear Dr. Creary,

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Jennifer Tucker, PhD

Staff Editor

PLOS ONE

Journal requirements:

When submitting your revision, we need you to address these additional requirements.

1.Thank you for stating the following in the Competing Interests section: 

"We have read the journal's policy and the authors of this manuscript have the following competing interests: Sebastian Seiguer is the co-founder and CEO of Scene Health. Lauren Brown and Katie Munshaw are employed by Scene Health. Scene Health owns trademarks, copyright, trade secrets, and know-how related to its video Directly Observed Therapy, which is the intervention for this trial.

In addition, Scene Health is collaborating with another small business, Impruvon Health, to develop the novel electronic adherence monitor that will be used in this study. Data from this trial may be used by Impruvon Health for future patent applications for that device."

Please confirm that this does not alter your adherence to all PLOS ONE policies on sharing data and materials, by including the following statement: "This does not alter our adherence to  PLOS ONE policies on sharing data and materials.” (as detailed online in our guide for authors http://journals.plos.org/plosone/s/competing-interests). If there are restrictions on sharing of data and/or materials, please state these. Please note that we cannot proceed with consideration of your article until this information has been declared. 

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Additional Editor Comments (optional):

As this study protocol received peer review as part of the funding process, we have expedited its handling for prompt publication. 

Reviewers' comments: