PONE-D-24-02018Assessing antioxidant, antidiabetic potential and GCMS profiling of ethanolic root bark extract of Zanthoxylum rhetsa (Roxb.) DC: Supported by in vitro, in vivo and in silico molecular modelingPLOS ONE

Dear Dr. HOSSAIN,

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Taye Beyene Demissie, PhD

Academic Editor

PLOS ONE

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Reviewers' comments:

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Comments to the Author

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Reviewer #1: Yes

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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5. Review Comments to the Author

Reviewer #1: Comments

1) The work is very interesting and studied for pre-clinical aspects. It will be useful for further research in the development of clinical studies.

2) It would be better to mention as anti-diabetes in the keywords instead of other words.

3) In silico should be in italics. In some instances, it is missing. It has to be checked and correct them.

4) In vivo should be corrected into italics.

5) References should be rechecked again according to the journal guidelines.

Report

The manuscript is well written and finds significance through in vitro, in vivo and in silico studies. My decision is ‘minor comments or revisions’. Therefore, I would strongly recommend the manuscript to be published in the Plos One Journal, after the above comments are addressed.

Reviewer #2: 

1. What is the rationale behind the selection of target proteins for anti diabetic potential? The diabetes Meletus involves complex pathogenesis and so many molecular pathways.

2. In, introduction the authors mentioned that there are no in-silico studies related to the anti oxidant activity. According to my opinion the authors should have gone for any significant protein/gene related to anti oxidant potential.

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Reviewer #1: No

Reviewer #2: No

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Assessing antioxidant, antidiabetic potential and GCMS profiling of ethanolic root bark extract of Zanthoxylum rhetsa (Roxb.) DC: Supported by in vitro, in vivo and in silico molecular modeling

PONE-D-24-02018R1

Dear Dr. HOSSAIN,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

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Kind regards,

Taye Beyene Demissie, PhD

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments: