PONE-D-23-37113Tuberculosis Treatment Outcomes and associated factors at Alemgena Health Center, Sebeta, Oromia, EthiopiaPLOS ONE

Dear Dr. Birri,

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PLOS ONE

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Partly

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: No

Reviewer #2: Yes

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3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: No

Reviewer #2: No

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: General comments: This manuscript has generated important data for TB control program in local context. However, it has limited global implication. If the authors re-write the manuscript including re-analysis it can be considered for publishing in Plos One.

Detail comments as follow;

Abstract

Result: Line 16-19: Please, avoid ambiguous words like about, nearly, almost all. Such words are frequently used even in the body of manuscript

Introduction:

Line 31-32: ---------. Humans are the only

reservoir for MTB. There are number recent report on MTB infections in animals how authors dare to say human are the only reservoir for MTB? Can authors justify?

Line 30-38: whole paragraph has no reference citation

Authors used almost same source of information, WHO report and advised to use scientific report/journal articles rather than using report. Moreover, authors used different citation style in one paper. For instance, author, date (WHO, 2021) and number in bracket (2). Authors should use Plos One reference style

Materials and Methods

Study design: Line 109: typo error . A 5 years………..was employed to to achieve……

Line: 111-121: Authors advised to organize under one sub-heading.

Ethical consideration

Although authors obtained ethical approval for study form ethical review board of Ayer Tena Health Science and Business College, they didn’t mention about consent of Alemgena health centre to give them permission to use their data for this study.

Results: Line 168-169: (standard deviation = 14.71). Nearly 90% (889/990) of the patients were in the age group 0-50----. Age can be <1 year, but how can be zero?

Line 181-182: Data on patient category, smear result, TB type and HIV status were not

available for 82, 381, 27 and 67 patients, respectively. What are the numbers 82, 381, 27 and 67?

Table 1: Line 188: what is the reason for categorizing transfer in together with new and relapse case? New and relapse can be linked to DRTB and transmission trend and transfer in link to what?

Reviewer #2: 1. Paragraph one lacks references

2. Reference system is mixed one another citations in side the body of the manuscript are not uniform (on the following line numbers: L44,45,46, 49,51,54, 56,58,60,62,65,83 the authors used text citations inside in the other part they used numbering system).

3. Line 87-89... the author used old version reference and it is advisable to put the recent updated reference instead.

4. Instead of a general reference to a 5-year retrospective study, it would be clearer to specify the exact time frame, such as ‘Institutional based retrospective study on a data collected from September 2012 to August 2018.' This removes any ambiguity and gives readers a precise understanding of the data analyzed as the study used specific health center data only.

5. Line number 136-138: in line 137 its advisable to check the grammar and put ‘used’ and ‘and’ next to ‘was’ and ‘outcomes’.

6. The author used old references and its recommended to use recent edition.

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Reviewer #1: No

Reviewer #2: Yes: Musse Girma abdela

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Tuberculosis Treatment Outcomes and associated factors at Alemgena Health Center, Sebeta, Oromia, Ethiopia

PONE-D-23-37113R1

Dear Dr. Birri,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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Kind regards,

Frederick Quinn

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

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3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

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5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

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6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: Now, authors substantially address all comments and I am satisfied with revision and recommended for publication

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7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: No

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