Peer Review History

Original SubmissionMay 8, 2023
Decision Letter - Miquel Vall-llosera Camps, Editor

PONE-D-23-13232Intolerance of Uncertainty and Mental Health in China “Post-pandemic” Age: The Mediating Role of Difficulties in Emotion RegulationPLOS ONE

Dear Dr. Li,

Thank you for submitting your manuscript to PLOS ONE. Firstly, we would like to apologize for the delay in processing your manuscript. It has been exceptionally difficult to secure reviewers to evaluate your study. We have now received one completed review, which is available below. The reviewer has raised significant scientific concerns about the study that need to be addressed in a revision.

Please note that we have only been able to secure a single reviewer to assess your manuscript. We are issuing a decision on your manuscript at this point to prevent further delays in the evaluation of your manuscript. Please be aware that the editor who handles your revised manuscript might find it necessary to invite additional reviewers to assess this work once the revised manuscript is submitted. However, we will aim to proceed on the basis of this single review if possible. 

After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

Please submit your revised manuscript by Aug 17 2023 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

Please include the following items when submitting your revised manuscript:

  • A rebuttal letter that responds to each point raised by the academic editor and reviewer(s). You should upload this letter as a separate file labeled 'Response to Reviewers'.
  • A marked-up copy of your manuscript that highlights changes made to the original version. You should upload this as a separate file labeled 'Revised Manuscript with Track Changes'.
  • An unmarked version of your revised paper without tracked changes. You should upload this as a separate file labeled 'Manuscript'.

If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter.

If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: https://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols. Additionally, PLOS ONE offers an option for publishing peer-reviewed Lab Protocol articles, which describe protocols hosted on protocols.io. Read more information on sharing protocols at https://plos.org/protocols?utm_medium=editorial-email&utm_source=authorletters&utm_campaign=protocols.

We look forward to receiving your revised manuscript.

Kind regards,

Miquel Vall-llosera Camps

Senior Editor

PLOS ONE

Journal Requirements:

When submitting your revision, we need you to address these additional requirements.

1. Please ensure that your manuscript meets PLOS ONE's style requirements, including those for file naming. The PLOS ONE style templates can be found at 

https://journals.plos.org/plosone/s/file?id=wjVg/PLOSOne_formatting_sample_main_body.pdf and 

https://journals.plos.org/plosone/s/file?id=ba62/PLOSOne_formatting_sample_title_authors_affiliations.pdf

2. We note that you have indicated that data from this study are available upon request. PLOS only allows data to be available upon request if there are legal or ethical restrictions on sharing data publicly. For more information on unacceptable data access restrictions, please see http://journals.plos.org/plosone/s/data-availability#loc-unacceptable-data-access-restrictions. 

In your revised cover letter, please address the following prompts:

a) If there are ethical or legal restrictions on sharing a de-identified data set, please explain them in detail (e.g., data contain potentially sensitive information, data are owned by a third-party organization, etc.) and who has imposed them (e.g., an ethics committee). Please also provide contact information for a data access committee, ethics committee, or other institutional body to which data requests may be sent.

b) If there are no restrictions, please upload the minimal anonymized data set necessary to replicate your study findings as either Supporting Information files or to a stable, public repository and provide us with the relevant URLs, DOIs, or accession numbers. For a list of acceptable repositories, please see http://journals.plos.org/plosone/s/data-availability#loc-recommended-repositories.

We will update your Data Availability statement on your behalf to reflect the information you provide.

3. We note that you have stated that you will provide repository information for your data at acceptance. Should your manuscript be accepted for publication, we will hold it until you provide the relevant accession numbers or DOIs necessary to access your data. If you wish to make changes to your Data Availability statement, please describe these changes in your cover letter and we will update your Data Availability statement to reflect the information you provide.

4. Your ethics statement should only appear in the Methods section of your manuscript. If your ethics statement is written in any section besides the Methods, please move it to the Methods section and delete it from any other section. Please ensure that your ethics statement is included in your manuscript, as the ethics statement entered into the online submission form will not be published alongside your manuscript. 

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

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3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: No

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: I have several concerns with presented manuscript in its current version mainly due to the methodological aspects.

1. The participants are not described in the introduction . I would recommend adding a summary table of the sociodemographic characteristics of the study participants.

2. The authors should add more details on sample selection. It is not completely clear how was it selected. Additionally, the authors do not propose a minimum sample size, and it is not clear what the reference population is?

3. The authors found a very low correlation of(- .09) between IUC and MH. Although it turned out to be significant, the assumed causal relationship that IUC led to MH seems questionable. The authors should emphasize that in the discussion and underline the need of further research to analyze the strength of these relationships.

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6. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: No

**********

[NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files.]

While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool, https://pacev2.apexcovantage.com/. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email PLOS at figures@plos.org. Please note that Supporting Information files do not need this step.

Revision 1

Response to Reviewer 1 Comments

Dear reviewer 1:

Thank you very much for your time involved in reviewing the manuscript and your comments have further improved the quality of the manuscript.

We have carefully reviewed the comments and revised the manuscript accordingly. The modified section was already highlighted in yellow. Hope the explanation has fully addressed all of your concerns. Point-by-point response to reviewer are attached below this letter.

Please see the attachment.

Point 1: The participants are not described in the introduction. I would recommend adding a summary table of the sociodemographic characteristics of the study participants.

Response 1: Many thanks for your comments, we have added a summary table of the sociodemographic characteristics of the study participants in the Results section (Table 1), for specific modifications see lines 246-252 of the manuscript.

Point 2: The authors should add more details on sample selection. It is not completely clear how was it selected. Additionally, the authors do not propose a minimum sample size, and it is not clear what the reference population is?

Response 2: Thank you for your suggestions. We have added details about the sample selection and the reasons for the selection, see lines 186-201 of the manuscript for specific corrections.

Also, we have supplemented the criteria for minimum sample size, see lines 204-208 of the manuscript for specific modifications.

Point 3: The authors found a very low correlation of(- .09) between IUC and MH. Although it turned out to be significant, the assumed causal relationship that IUC led to MH seems questionable. The authors should emphasize that in the discussion and underline the need of further research to analyze the strength of these relationships.

Response 3: Your advice makes a lot of sense. We speculate that the low correlation between IUC and MH also constitutes a realistic reason for the complete mediating role of DER between IUC and MH in this study. Therefore, we have supplemented and explained this reason in the Discussion section, as detailed in lines 338-342 of the manuscript.

Furthermore, since this study was a cross-sectional design, a causal relationship was not assumed. This is mentioned in the Limitations section (as detailed in lines 382-384). At the same time, we also underlined the need for further research to analyze the strength of these relationships in the Research limitations section, as detailed in lines 388-391 of the manuscript.

Attachments
Attachment
Submitted filename: Response to Reviewer 1 Comments.docx
Decision Letter - Nebojsa Bacanin, Editor

PONE-D-23-13232R1Intolerance of Uncertainty and Mental Health in China “Post-pandemic” Age: The Mediating Role of Difficulties in Emotion RegulationPLOS ONE

Dear Dr. Li,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

==============================

ACADEMIC EDITOR: Dear Authors,please revise your manuscript carefully. All the best

==============================

Please submit your revised manuscript by Dec 28 2023 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

Please include the following items when submitting your revised manuscript:

  • A rebuttal letter that responds to each point raised by the academic editor and reviewer(s). You should upload this letter as a separate file labeled 'Response to Reviewers'.
  • A marked-up copy of your manuscript that highlights changes made to the original version. You should upload this as a separate file labeled 'Revised Manuscript with Track Changes'.
  • An unmarked version of your revised paper without tracked changes. You should upload this as a separate file labeled 'Manuscript'.

If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter.

If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: https://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols. Additionally, PLOS ONE offers an option for publishing peer-reviewed Lab Protocol articles, which describe protocols hosted on protocols.io. Read more information on sharing protocols at https://plos.org/protocols?utm_medium=editorial-email&utm_source=authorletters&utm_campaign=protocols.

We look forward to receiving your revised manuscript.

Kind regards,

Nebojsa Bacanin

Academic Editor

PLOS ONE

Additional Editor Comments (if provided):

Dear Authors,

please revise proposed manuscript thoroughly according to all reviewers' comments.

Additionally, please do the following:

- Visualization of obtained results must be improved

- Motivation behind proposed research should be more clearly explain. Please elaborate what is "beyond state-of-the-art" of proposed. study.

- Make sure that the source code is available according to PLOS ONE publication policies.

- Make sure that you have conducted rigid statistical analysis.

All the best,

AE

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

Reviewer #2: (No Response)

Reviewer #3: All comments have been addressed

**********

2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Partly

Reviewer #3: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: No

**********

5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: The authors have adequately addressed my comments raised in a previous round of review and I feel that this manuscript is now acceptable for publication.

Thank you.

Reviewer #2: 1. State the research question clearly in the Introduction.

2. List the main contributions in the Introduction.

3. Provide paper structure at the end of the Introduction.

4. Literature survey should be expanded, especially with recent papers dealing with COVID19. You can include the following:

https://www.sciencedirect.com/science/article/pii/S2210670720308842

https://link.springer.com/article/10.1007/s00521-022-07424-w

https://link.springer.com/chapter/10.1007/978-981-19-1653-3_35

https://www.sciencedirect.com/science/article/pii/S0045790622003159

https://www.nature.com/articles/s41598-022-06218-3

5. The contribution of the research to the field should be justified better.

6. Provide more details about the utilized questionary.

7. Discussion should be more elaborate.

8. Discuss the limitations of the research as well.

9. Conclusion is very limited - it should summarize up the research, mention the most important findings and limitations of the research, and indicate future research in this topic.

10. Thorough proofreading of the paper is recommended.

Reviewer #3: The authors took care of the recommendations. However, the data set that is made available is not intelligible. The columns of the table are not in English and the meaning of the values is not explained.

Please add a description of the data set where it is made available and use English for the header in order to make it usable.

**********

7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: No

Reviewer #2: No

Reviewer #3: No

**********

[NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files.]

While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool, https://pacev2.apexcovantage.com/. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email PLOS at figures@plos.org. Please note that Supporting Information files do not need this step.

Revision 2

Response to Reviewer 2 Comments

Dear reviewer 2:

Thank you very much for your time involved in reviewing the manuscript, and your comments have further improved the quality of the manuscript.

We have carefully reviewed the comments and revised the manuscript accordingly. The modified section was already highlighted in yellow. Hope the explanation has fully addressed all of your concerns. Point-by-point response to reviewer are attached below this letter.

Please see the attachment.

Q1. State the research question clearly in the Introduction.

Reply: Many thanks for your comments. We have added the research question of this study in the Introduction, for specific modifications see lines 66-72 of the manuscript.

Q2. List the main contributions in the Introduction.

Reply: Thank you for your suggestions. We have added the main contributions in the Introduction, for specific modifications see lines 72-75 of the manuscript.

Q3. Provide paper structure at the end of the Introduction.

Reply: Many thanks for your comments. We have provided paper structure, for specific modifications see lines 174-193 of the manuscript.

Q4. Literature survey should be expanded, especially with recent papers dealing with COVID19. You can include the following:

Reply: Thank you for the professional references you provided. We have carefully read these references and added them to the manuscript. For the specific content, please see lines 42-46, 347-372 and 373-393 of the manuscript.

Q5. The contribution of the research to the field should be justified better.

Reply: Thank you for your suggestions. We have added the contribution of the research to the field, for specific modifications see lines 373-393 of the manuscript.

Q6. Provide more details about the utilized questionary.

Reply: Many thanks for your comments. We have provided more details about the utilized questionary. For specific content see Table 3 (lines 283-286) .

Q7. Discussion should be more elaborate.

Reply: Thank you for your suggestions. We have enriched the discussion, for specific modifications see lines 347-372 of the manuscript.

Q8. Discuss the limitations of the research as well.

Reply: Many thanks for your comments. The discussion of the limitations and the future research recommendations are presented in lines 429-439 of the manuscript.

Q9. Conclusion is very limited, it should summarize up the research, mention the most important findings and limitations of the research, and indicate future research in this topic.

Reply: Thank you for your suggestions. We have enriched the Conclusion, for specific modifications see lines 416-422 of the manuscript. Furthermore, the discussion of the limitations and the future research recommendations are presented in lines 429-439 of the manuscript.

Q10. Thorough proofreading of the paper is recommended.

Reply: Thank you for your suggestions. We have proofread the revised manuscript.

Response to Reviewer 3 Comments

Dear reviewer 3:

Thank you very much for your time involved in reviewing the manuscript and your comments have further improved the quality of the manuscript.

We have carefully reviewed the comments and revised the manuscript accordingly. The modified section was already highlighted in yellow. Hope the explanation has fully addressed all of your concerns. Point-by-point response to reviewer are attached below this letter.

Please see the attachment.

Point: The data set that is made available is not intelligible. The columns of the table are not in English and the meaning of the values is not explained. Please add a description of the data set where it is made available and use English for the header in order to make it usable.

Response: Many thanks for your comments. We have unified the abbreviations in the data with those within the manuscript and changed them to English. Meanwhile, we also submitted a "Data availability statement" with this statement as a detailed description of the data set and the meaning of these abbreviations.

The data used in this paper and the description of the data set are openly available at the OSF site for this paper at https://osf.io/fme5s/, DOI 10.17605/OSF.IO/FME5S.

Attachments
Attachment
Submitted filename: Response to Reviewer 3 Comments.docx
Decision Letter - Nebojsa Bacanin, Editor

Intolerance of Uncertainty and Mental Health in China “Post-pandemic” Age: The Mediating Role of Difficulties in Emotion Regulation

PONE-D-23-13232R2

Dear Dr. Li,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

An invoice for payment will follow shortly after the formal acceptance. To ensure an efficient process, please log into Editorial Manager at http://www.editorialmanager.com/pone/, click the 'Update My Information' link at the top of the page, and double check that your user information is up-to-date. If you have any billing related questions, please contact our Author Billing department directly at authorbilling@plos.org.

If your institution or institutions have a press office, please notify them about your upcoming paper to help maximize its impact. If they’ll be preparing press materials, please inform our press team as soon as possible -- no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org.

Kind regards,

Nebojsa Bacanin

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Dear Authors,

thank you for revising your manuscript.

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #2: All comments have been addressed

Reviewer #3: All comments have been addressed

**********

2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #2: (No Response)

Reviewer #3: (No Response)

**********

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #2: (No Response)

Reviewer #3: (No Response)

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #2: (No Response)

Reviewer #3: (No Response)

**********

5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #2: (No Response)

Reviewer #3: (No Response)

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #2: (No Response)

Reviewer #3: (No Response)

**********

7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #2: No

Reviewer #3: No

**********

Formally Accepted
Acceptance Letter - Nebojsa Bacanin, Editor

PONE-D-23-13232R2

PLOS ONE

Dear Dr. Li,

I'm pleased to inform you that your manuscript has been deemed suitable for publication in PLOS ONE. Congratulations! Your manuscript is now being handed over to our production team.

At this stage, our production department will prepare your paper for publication. This includes ensuring the following:

* All references, tables, and figures are properly cited

* All relevant supporting information is included in the manuscript submission,

* There are no issues that prevent the paper from being properly typeset

If revisions are needed, the production department will contact you directly to resolve them. If no revisions are needed, you will receive an email when the publication date has been set. At this time, we do not offer pre-publication proofs to authors during production of the accepted work. Please keep in mind that we are working through a large volume of accepted articles, so please give us a few weeks to review your paper and let you know the next and final steps.

Lastly, if your institution or institutions have a press office, please let them know about your upcoming paper now to help maximize its impact. If they'll be preparing press materials, please inform our press team within the next 48 hours. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org.

If we can help with anything else, please email us at customercare@plos.org.

Thank you for submitting your work to PLOS ONE and supporting open access.

Kind regards,

PLOS ONE Editorial Office Staff

on behalf of

Dr. Nebojsa Bacanin

Academic Editor

PLOS ONE

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