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PONE-D-23-26576Prevalence of DSM-5 mild and major neurocognitive disorder in India: Results from the LASI-DADPLOS ONE

Dear Dr. Gross,

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PLOS ONE

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Reviewers' comments:

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Comments to the Author

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Reviewer #1: Yes

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

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3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: The authors used data from a nationally representative sample to determine the prevalence of neurocognitive disorders in India. The used the DSM-5 criteria to construct the variable of interest. The topic is extremely relevant and the manuscript is well-written and informative. I have a few concerns:

1) Equating neurocognitive disorder as constructed here with MCI and AD may have some issues. What implications do the sensitivity and specificity of the diagnostic construct used here have on the final prevalence estimates?

2) The discussion can include something brief on the sensitivity analysis - why was it considered and what are the implications of the result of the sensitivity analysis?

3) The article is silent on the linguistic diversity of India. How many language versions were used? Would linguistic diversity affect the estimates or not?

Reviewer #2: 1. Number of women in India reporting to dementia clinics/memory clinics is significantly less compared to men; and this gender bias has been reported widely. Please clarify this based on your data.

2. Please specify clearly where and how the sample were collected.

3. Authors are concluding that the data reported in the study has higher prevalence than previously reported data; however, line 84 & 85 suggests that the participants and informants were interviewed both from home and hospital. Hence this claim looks superfluous.

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Reviewer #1: No

Reviewer #2: Yes: Dr Vikas Dhikav, Medical Scientist-E, ICMR-DHR, MoHFW, Govt of India, New Delhi

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Prevalence of DSM-5 mild and major neurocognitive disorder in India: Results from the LASI-DAD

PONE-D-23-26576R1

Dear Dr. Gross,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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Kind regards,

Amina Nasri

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

Reviewer #2: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

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5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: I commend the authors' efforts to incorporate the suggestions made for improving the manuscript. The manuscript is a useful addition to knowledge in this area.

Reviewer #2: Looks much better. The response to the comments have been addressed. Gender bias in reporting dementia is an important aspect of seeking dementia care in India reported in few studies.

This may be cause of a number of factors e.g. perceived importance of seeking care, gender issues prevalent in society and may be cause of lack of awareness about dementia care for women in general.

The last point however pertains to both. Still, this is an important aspect of dementia/memory clinic service utilisation which has been noticed by several clinician colleagues.

Authors have clarified the issue related to sampling, its process and the way the conclusions have been drawn which has improved the clarity of the manuscript overall.

Authors have clarified that participants were interviewed in a hospital

setting if they lived near a participating hospital and preferred to be interviewed there

rather than at home. Though authors state that they do not believe the location of interview would affect their results- to avoid confusion for readers, authors have revised the manuscript to remove the sentence.

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7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: Yes: Ravi Prasad Varma

Reviewer #2: Yes: Vikas Dhikav, Scientist-E (Medical), ICMR-Department of Health Research, MoHFW, Govt of India

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