PONE-D-23-00874Spatial variation and determinants of age-appropriate vaccination practice in Ethiopia using EDHS 2016 data: A multilevel and spatial analysisPLOS ONE

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Your manuscript has been reviewed by two reviewers. Based on the review reports, and my own assessment as Editor, I am pleased to inform you that it has a potential to be accepted for publication in PLOS ONE, once you have significantly carried out revisions suggested by the reviewers. Therefore, we invite you to significantly revise the manuscript.

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

********** 2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

**********3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

********** 4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: No

Reviewer #2: Yes

********** 5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: The authors tried to assess the spatial variation and determinants of age-appropriate vaccination practice in Ethiopia using EDHS 2016 data. Then they concluded as the spatial distribution of age-appropriate vaccination practice in Ethiopia was non-randomly distributed across the regions. Age-appropriate vaccination practice was low in Ethiopia. Wealth index, usual caretaker of the child, ANC utilization, history of TT vaccination, place of delivery, and residence were associated with age-appropriate vaccination practice. The idea of good.

• The manuscript needs to take an editorial revision to tackle minor grammar issues.

• I suggest that the authors consider more updated references to the introduction subsection.

• To clearly indicate and just the existence of the spatial variation, it is also highly important if some spatial tests are taken into account. With these comments, I recommend that the article be published.

• I don’t see the effects of age when dealing the spatial issues. What is the relevance of considering age as one of the explanatory variables in dealing with spatial analysis?

• I also suggest the authors to highlight and explain the issue of spatial dependency in the methodology subsection.

Regards

Habte Tadesse, PhD

Department of statistics, Addis Ababa University, Ethiopia

Reviewer #2: Comments to author(s)

Manuscript Number: PONE-D-23-00874

Title: Spatial variation and determinants of age-appropriate vaccination practice in Ethiopia using EDHS 2016 data: A multilevel and spatial analysis

I appreciate the authors for their effort to conduct this study. The manuscript reports findings based on the objective of the study. The overall organization of the manuscript is also good. But, there are some concerns that need corrections. The comments are listed below, review and amend them.

Introduction

Some of your references cited in the introduction part has no relation to your document.

Citation #1 talks about “The impact of the vaccination program for hemorrhagic fever with renal syndrome in Hu County, China”, remove this citation and replace it with appropriate citation.

Citation #2 briefs about influenza vaccine not about period of vaccine administration. Revise and replace with the appropriate citations.

Citation #3 is not the finding of the research you cited. Rather, you used from cross reference. So, replace it with appropriate source,

Page 3, line 58-59; revise the sentence. Next to citation 6, please add the program of vaccination based on WHO recommendation.

Page 4, line 71; write full words on their first appearance, VPDs.

Page 4, line 76; the citation used for Toke kutaye reference number 18 is not correct. The reference listed on number 18 is Xiao X, Wu Z-C, Chou K-C , 2011.

Methods

Page 4, line 84-85; the population of Ethiopia is 114,963,588, include your reference

Page 4, line 89-90; what is the need of this statement “the Ethiopian demographic health survey of 2016 revealed that among ten children aged 12-23, four children (39%) received all the basic vaccines (19).:”?

Page 6, line 119; table 1, there is no table clearly showing table 1 since table cations are 1 for all.

Results

Page 7, line 144, line 149, and page 9 line 200; you cited table 2,3, and 4, but not appropriately used the captions.

Page 8, line 162; figure 4 is not available in lists of tables or has no caption.

Pages 7- 8, line 158-162; why you included about anemia? Remove it.

Discussion

At the end of your discussion add strength and limitation of your study.

Conclusion

Actually, you have no variable that shows lack of transportation fees. So, you could not give the following recommendation since it is not a part of your findings. So remove it. “provide outreach vaccination for those are difficulty accessing the vaccine because of lack of transport fees could bring a significant contribution to improving age appropriate vaccination practice by health care workers.”

Page 12, line 264-266; move the strength and limitation to discussion part.

References

References 1-3 are not related with your citation, so change and update them.

Reference number 19 is not fully written. Revise it.

Tables

There are 4 tables listed in the manuscript. But the caption of each table is not correct. All tables are labeled as “table 1”, revise and correct them.

Sociodemographic table, under variable region, change Somalia to Somali.

Figures

Out of the 7 figures listed in in this manuscript, one figure has no caption. Revise it.

********** 6. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

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Reviewer #1: Yes: ok

Reviewer #2: No

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Attachments

Attachment

Submitted filename: Comments to authors-1.docx

Spatial pattern and associated factors of timely vaccination in Ethiopia using EDHS-2016 data: A multilevel and spatial analysis

PONE-D-23-00874R1

Dear Dr. chanie,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

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Kind regards,

Gizachew Gobebo Mekebo

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #2: (No Response)

**********

2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #2: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #2: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #2: Yes

**********

5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #2: Yes

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #2: (No Response)

**********

7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #2: No

**********