Endoscopic mucosal resection versus endoscopic submucosal dissection for colorectal adenomas and tumors: meta-analysis and systematic review

PONE-D-23-12685

Dear Dr. Xinghuang Liu

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PLOS ONE

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Reviewer #1: Yes

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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5. Review Comments to the Author

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Reviewer #1: The authors have reported their metanalysis comparing safety, efficacy and long-term outcome between endoscopic submucosal dissection (ESD) and endoscopic mucosal resection (EMR). The authors have reported their meta-analysis aiming to assess effectiveness and safety of ESD vs. EMR early rectal cancer. Unfortunately, only retrospective were included, with highly heterogeneous patient and surgical procedure characteristics. However, literature is clearly heterogenous and this paper show a new point of view on selection of patients.

Author could discussed the results in the western countries.

This subject is very interesting, and we need today to have some all results of therapeutic in order to limit impact of functional consequence of our strategies.

This paper was clear, and conclusion about this was strong.

Reviewer #2: interesting current work, the bibliography is rich recent in adequacy with the subject, this manuscript is to published , the data is important and the study is too . The results are interesting, satisfactory and correct, the conclusions are in line with the objectives of the study

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Reviewer #1: No

Reviewer #2: Yes: Dr Ramzi GRAICHI

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