PONE-D-23-12302Screening for temporomandibular disorders in patients with dentofacial deformities: impacts on life quality and salivary biomarkersPLOS ONE

Dear Dr. Campos,

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

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3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: Dear Authors,

thank you for giving me the opportunity to revise your paper entitled " Screening for temporomandibular disorders in patients with dentofacial deformities: impacts on life quality and salivary biomarkers". The paper aims to explore the incidence of TMD in dentofacial deformities. The MS is well written and succinct, but there are some critical issues to ad-dress that makes the paper unsuitable for publication in Journal:

1. The Title is quite confuse and doesn’t explain the study sample. Please, change it

2. Please, delete in Abstract the sentence “in orthodontic treatment before surgical correction; n=17 each”

3. The introduction is quite poor of different clinical information. I suggest to improve it in terms of possible therapeutic approaches in TMD. Please, refer also to new conservative approaches ( “Marotta N, Ferrillo M, Demeco A, Drago Ferrante V, Inzitari MT, Pellegrino R, Pino I, Russo I, de Sire A, Ammendolia A. Effects of Radial Extracorporeal Shock Wave Therapy in Reducing Pain in Patients with Temporomandibular Disorders: A Pilot Randomized Controlled Trial. Applied Scien-ces. 2022”; 12(8):3821. https://doi.org/10.3390/app12083821)

5. Please, add the study design in the introduction

6. Please, delete in Material and Methods the sentence in brackets (n=17 each).

7. Results are well written

8. Please, add the clinical implication of your founding

9. Please, add the Conclusion

Best Regards

Reviewer #2: Dear Corresponding Author,

The paper is really interesting, well conducted and fits the objectives of the journal; but it is necessary to review some points in order to improve the quality of the paper:

1) First, i ask you to check the plagiarism of your article using Ithenticate

2) About the Title of the article, I suggest you to modify it and add the type of article.

3) The Abstract is precisely written, and the aim of the study is mentioned.

4) The introduction section is very short and is needed to add other references to increase the quality of the manuscript. I suggest you add some lines on the impact of quality of life in patients with TMD and the prevalence of TMD in children and adolescents. I suggest including the following articles in the bibliography to enhance the impact of the paper. [10.1111/joor.13446]; [10.1111/joor.13472]

5) The Material and Methods section is adequate and well organized, but punctuation and spaces between words should be reviewed.

6) The conclusion is in accordance with the objectives of the research, its results and their interpretation, as well as the relevant literature. I suggest you include a section on study limitation.

Regards

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Reviewer #1: No

Reviewer #2: No

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Assessment of temporomandibular disorders and their relationship with life quality and salivary biomarkers in patients with dentofacial deformities: a clinical observational study

PONE-D-23-12302R1

Dear Dr. Maria M. Campos,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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Kind regards,

Martina Ferrillo

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Authors modified the text according to the suggestions.

I found this work impactful and it fits well with in the scope of this journal.

In my opinion, it is suitable for publication.

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

Reviewer #2: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

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3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

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5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

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6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: (No Response)

Reviewer #2: Dear authors,

I am satisfied with the changes made

The article is well carried out and the changes have been incorporated and implemented in the text

Regards

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7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: Yes: Dario calafiore

Reviewer #2: No

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