Peer Review History
| Original SubmissionDecember 12, 2021 |
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PONE-D-21-39237Does Grit Protect Against the Adverse Effects of Depression on Academic Performance?PLOS ONE Dear Dr. Kilgore, Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process. I received reviews from two scholars who are experts in your field of study and have also read your manuscript independently and prior to reading their reviews. Overall, the reviews are mixed. One reviewer recommends rejection while the other sees potential in your paper but suggests a major revision. While I share the concerns both reviewers raised, I would support a risky major revision. R1 has not offered specifics but raised general concerns regarding the exposition and development of the theory as well as the discussion and conclusion. R2 offers excellent and very detailed points, which showcase some of the shortcomings of the current version of the manuscript. Next (and in addition) to these points, I found that the introduction lacks a clear theoretical foundation. The constructs (Grit, Social Desirability, Depressive Symptoms, and GPA) and their theoretical connection needs to be much better explained and motivated. Why are these studied and not others? An overarching theoretical framework is missing. Instead, it seems as though they are chosen simply because they might be related to grit. Additionally, and this may be the most pertinent issue, it is not clear why it is important to further research this topic? Regarding this point it may not be enough to point out that there is an inconsistency in the literature without providing further details on how your study furthers our understanding of the studies constructs and their theoretical foundation. Also, please clearly state your contribution. Similarly, next to providing a more solid foundation for you research question, the hypotheses could also be better motivated. For example, I did not understand the theoretical foundation for H5… In the method, please be more precise in the information that you offer. R2 provides some good points for this, but please also indicate which country the study was conducted. You currently state that the data was collected in a Southeastern University. This could mean anything from the Southeast in the USA to Indonesia (Southeast Asia) to Greece (Southeast Europe). In the Results, you indicate how you cleaned the data. As a substantial number of participants were excluded, please provide a better and more convincing rationale for exclusion (e.g., why were participants with more than 33 data points excluded)? Also, please indicate either in the text or in a footnote how the main results changed (if at all) if these participants are not excluded. In your analyses, R2 suggests using an SEM approach in order to present a more coherent and cohesive picture of your results. While this is possible, I think it would suffice if you ran one big model (the moderated moderation) rather than three individual moderations. There are at least two problems with the data analysis that you currently offer. First, there is a chance of inflated alpha since you are conducting several moderations with duplicate IVs. Second, the results you present are in part redundant. Both of these issues can be solved by only presenting one moderated moderation. The discussion lacks a deeper treatment of the examined constructs and what the results mean. In fact, the theoretical contribution of the paper needs to be sharpened considerably. Additionally, and in light of the unclear contribution, I would urge you to be careful in your interpretation of your null findings. While the first three hypotheses seem to be merely replications of prior research, the predicted moderation between grit and depressive symptoms on GPA did not materialize. What exactly does that mean (theoretically and practically)? Can we therefore conclude that grit never moderates the effects of depressive symptoms, or is this the outcome of just one (your) study? The limitation section needs considerable attention, as it does not add much to the manuscript in its current form. More insights on why grit did not emerge as a moderator need to be discussed here. Additionally, what evidence do you have that people who exhibit high social desirability inflate their grit scores? This is assumed in the manuscript (and by prior research), but you do not offer evidence of this in your study. Also, in the limitations section you might add a discussion on recent evidence that casts doubt on (parts of) the grit concept (see Duckworth, Quinn & Tsukayama, 2021). Given the comments from the reviewers (and my own), the manuscript does not meet the following publication criteria from PLOS ONE: #3 (“Experiments, statistics, and other analyses are performed to a high technical standard and are described in sufficient detail”) and #4 (“Conclusions are presented in an appropriate fashion and are supported by the data”). I am therefore inviting a (risky) major revision. Should you resubmit, please read all comments carefully and respond to each of them in detail. Please submit your revised manuscript by Jun 04 2022 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file. Please include the following items when submitting your revised manuscript:
If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter. If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: https://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols. Additionally, PLOS ONE offers an option for publishing peer-reviewed Lab Protocol articles, which describe protocols hosted on protocols.io. Read more information on sharing protocols at https://plos.org/protocols?utm_medium=editorial-email&utm_source=authorletters&utm_campaign=protocols. We look forward to receiving your revised manuscript. Kind regards, Stephan Dickert, Ph.D. Academic Editor PLOS ONE Journal Requirements: When submitting your revision, we need you to address these additional requirements. 1. Please ensure that your manuscript meets PLOS ONE's style requirements, including those for file naming. The PLOS ONE style templates can be found at https://journals.plos.org/plosone/s/file?id=wjVg/PLOSOne_formatting_sample_main_body.pdf and 2. We note that the grant information you provided in the ‘Funding Information’ and ‘Financial Disclosure’ sections do not match. When you resubmit, please ensure that you provide the correct grant numbers for the awards you received for your study in the ‘Funding Information’ section. 3. We note that you have stated that you will provide repository information for your data at acceptance. Should your manuscript be accepted for publication, we will hold it until you provide the relevant accession numbers or DOIs necessary to access your data. If you wish to make changes to your Data Availability statement, please describe these changes in your cover letter and we will update your Data Availability statement to reflect the information you provide. 4. Please include your full ethics statement in the ‘Methods’ section of your manuscript file. In your statement, please include the full name of the IRB or ethics committee who approved or waived your study, as well as whether or not you obtained informed written or verbal consent. If consent was waived for your study, please include this information in your statement as well. [Note: HTML markup is below. Please do not edit.] Reviewers' comments: Reviewer's Responses to Questions Comments to the Author 1. Is the manuscript technically sound, and do the data support the conclusions? The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented. Reviewer #1: Partly Reviewer #2: No ********** 2. Has the statistical analysis been performed appropriately and rigorously? Reviewer #1: No Reviewer #2: No ********** 3. Have the authors made all data underlying the findings in their manuscript fully available? The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified. Reviewer #1: No Reviewer #2: No ********** 4. Is the manuscript presented in an intelligible fashion and written in standard English? PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here. Reviewer #1: Yes Reviewer #2: No ********** 5. Review Comments to the Author Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters) Reviewer #1: Thank you for the opportunity to read this interesting paper. The paper is well-written and easy to read. I think it is timely and important to investigate the conditions that may facilitate or hinder people’s achievements, especially in the light of depressive symptoms, which are now so common. There are, however, a number of issues that I think should be solved, which I now outline. As an aside, with any resubmission, I would suggest the authors provide line numbers to aid with the revision work. Title: I am not sure the words “Academic performance” are indicative of your study. Academic performance may be regarded as the performance of people working in academia, which however is very different compared to students’ performance during their study. Abstract: No information is reported regarding the study design (cross-sectional? Longitudinal? Field study? Experimental?), context, and participants (students? How many? From which country?). I would suggest revising the abstract to include this essential information. The way findings are currently described makes it unclear how each variable was treated. I would suggest the authors describe their overall model or present their hypotheses to aid comprehension of what was done. Introduction: Overall, I have the feeling that the introduction is somewhat poorly developed, without consistent reasoning that links together all the different hypotheses. On page 10, when describing the role of depressive symptoms, you start by describing how gritty individuals may not “retain” their grit in the presence of depressive symptoms and then go on describing that, on the opposite, an individual “who is gritty might be protected…” Hence, at first, it seems that “depressive symptoms” act as a boundary condition influencing the extent to which grit may lead to long term-goals, while in the second part of the paragraph you describe how grit represents a boundary condition influencing the link between depressive symptoms and the avoidance of positive situations. I found this confusing. I would suggest clarifying what the main relationship you are focusing on is, i.e., grit -> long-term goals or depressive symptoms -> avoidance of positive stimuli/situation and then describe the moderating role of grit/depressive symptoms consistently. At the end of page 4/ beginning of page 5, you propose that “examining two constructs (grit and depressive symptoms) that appear to oppositely relate to GPA may be of interest”. I think that, given your study design, what may be more interesting is investigating the boundary conditions that may influence the extent to which grit may relate to GPA. Moreover, rather than just suggesting that doing such an investigation is “of interest”, I would suggest spelling out why this is important and how this contributes to advancing knowledge in meaningful ways. Overall, I think the hypotheses could be better grounded in previous literature and incorporated in the introduction / theoretical background (particularly the latter seems lacking in the current form of the manuscript). Hypothesis 1 is remarkably underdeveloped, and the authors may provide stronger arguments for the others in what is presented in the pages before. Given the way the paper is currently structured, I would have expected the authors to consider the link between grit and GPA as the main relationship investigated, while from the hypotheses it seems that the main relationship is the one between depressive symptoms and achievement, with grit (and social desirability) being boundary conditions influencing such a relationship. Importantly, the way the hypotheses are currently presented – and the intro is currently structured – gives the feeling of a lack of a coherent idea behind the paper, with many “stand-alone” relationships hypothesized, while I think the paper has the potential to integrate all the hypotheses in a single model. Moreover, while I understand that the authors aim to contribute to the literature by investigating whether social desirability strengthens or lessens the “impact” of grit on achievement (here: GPA), the proposed argument seems to point to social desirability as a variable to control for, rather than as a focal variable of the proposed relationships between depressive symptoms, grit, and achievement. Method: I would suggest describing the final sample, including age, gender, and descriptive data, directly in the participant paragraph. Can you provide more details regarding the recruitment procedure? What information was given to the participants regarding the study aims? I saw that participants’ age is reported in Table 1, but it should also be reported in the text. What year were they enrolled in? Were all your participants American? When were surveys administered, also with regards to the academic year? Was the study conducted during the COVID pandemic? If so, how could this have affected your results? Was your sample representative of the population? Measures: Please provide at least a sample item for each scale. Depressive Symptoms: what response scale was used for this measure? Given the international audience of the journal, I would suggest the authors spell out GPA and at least define/explain how this is calculated and its range. How could your data be affected by the fact that surveys were not anonymous? On page 10, you report “Any outliers more than three standard deviations above or below the mean were adjusted to three standard deviations above or below the mean as is standard practice”. Can you provide references for this? While reliability of the measures is reported, CFA should also be conducted to assess validity. Test of Hypotheses: I have the feeling that the analyses should be re-run using SEM so as to test all the hypotheses in one single model – also based on any revised introduction (see comments above). The adopted procedure is not parsimonious. Given the issues with the introduction, method, and results described, it is unclear what can be concluded from the study. Hence, with any revision, discussion and conclusions should also be revised. Table 1: Please spell out the acronyms in a note. In the table, you refer to “QIDS-SR (8-item)” while in the text you refer to a 15-item version. Please clarify. Also, please clarify the response scale for each scale used. Reviewer #2: The introduction provides a poor background of the topic that does not give to the reader an appreciation of the wide range of the constructs here studied. The objective of the study as well as the results could be more developed. Discussion and conclusion are poor written. ********** 6. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files. If you choose “no”, your identity will remain anonymous but your review may still be made public. Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy. Reviewer #1: No Reviewer #2: No [NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files.] While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool, https://pacev2.apexcovantage.com/. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email PLOS at figures@plos.org. Please note that Supporting Information files do not need this step. |
| Revision 1 |
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PONE-D-21-39237R1Does Grit Protect Against the Adverse Effects of Depression on Academic Achievement?PLOS ONE Dear Dr. Collins, Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process. Also, please ensure you improve the methodological and analysis elements of the paper. For instance, were effect sizes calculated for standardised betas? Another, how did you address the issue of endogeneity? An argument supporting the use of cross-sectional design would enrich the discussion. Please submit your revised manuscript by Mar 25 2023 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file. Please include the following items when submitting your revised manuscript:
If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter. If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: https://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols. Additionally, PLOS ONE offers an option for publishing peer-reviewed Lab Protocol articles, which describe protocols hosted on protocols.io. Read more information on sharing protocols at https://plos.org/protocols?utm_medium=editorial-email&utm_source=authorletters&utm_campaign=protocols. We look forward to receiving your revised manuscript. Kind regards, Ali B. Mahmoud, Ph.D. Academic Editor PLOS ONE [Note: HTML markup is below. Please do not edit.] Reviewers' comments: Reviewer's Responses to Questions Comments to the Author 1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation. Reviewer #1: (No Response) Reviewer #3: (No Response) ********** 2. Is the manuscript technically sound, and do the data support the conclusions? The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented. Reviewer #1: Partly Reviewer #3: Yes ********** 3. Has the statistical analysis been performed appropriately and rigorously? Reviewer #1: Yes Reviewer #3: No ********** 4. Have the authors made all data underlying the findings in their manuscript fully available? The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified. Reviewer #1: No Reviewer #3: Yes ********** 5. Is the manuscript presented in an intelligible fashion and written in standard English? PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here. Reviewer #1: Yes Reviewer #3: Yes ********** 6. Review Comments to the Author Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters) Reviewer #1: Thank you for the significant revisions to the paper. I think it definitely improved compared to the previous version. This being said, there are some aspects that I think could still be clarified to improve the value of the paper. Abstract I think the abstract is now much easier to follow. However, I also think that the role of social desirability in the model is still somewhat unclear and unexpected given that the very first sentences (lines 27-28) mainly refer to grit. I would suggest the authors describe the inclusion of social desirability right after grit so that it is clear how/why this is part of the study. Intro: I find this version of the introduction much more compelling and better structured. I still have the following comments: Lines 72-73: I do not follow how the fact that grit may not consistently predict academic success across domains is linked to your study. This seems to suggest that you investigate this link across different domains, but this was not the case. I think that the opening of the paragraph “Research questions and hypotheses” could be clearer. On line 103 you report that “individuals with higher levels of grit experience lower depressive symptoms”, implying that (high) grit leads to (lower) depressive symptoms. Please report a reference here so that it is clear upfront that this is what previous research shows – and not what your study is about. Results: When reading your results, I was wondering whether you controlled for age and year of enrollment. I would be curious to know if anything changes. Line 246: You report that “grit is not a promising factor… when considering social desirability”. I would suggest adding - “even” when considering social desirability-, given that your results show that grit alone was also not significantly related to achievement. Line 247-248: How did your results show that social desirability impacts the validity of grit when assessed via self-reported measures? Minor: Given that your study is cross-sectional, please avoid the use of terms that imply causality (e.g., impact, line 35). Reviewer #3: The efforts put in by the authors are commendable, considering the criticality of the opted research topic. Moreover, the research team has highlighted the academic and practical implication of the presented study very well. Having that said, the following suggestions will assist to improve the manuscript further: 1- Introduction & Literature Support: The authors have successfully communicated the need of conducting the research on the topic of interest, but the provided literature support (in-depth explanation with enough references) for the variables of interest and hypothesized relationships (direct & indirect) is missing. Therefore, a potential reader my remain unconvinced to see the broader impact of the selected variables. 2- Method & Analysis: The presented research does a good job in explaining the selected sample and concluding the results. Having that said there are few gaps that need to be addressed including: - Why was the initial sample of 625 (final count=520) was opted? An explanation is required in terms of relating it to the population of interest. As this will define the scope of generalization for the presented research. - Why was G-Power utilized in comparison to the other statistical tools to determine the results. An brief explanation supporting the accuracy of the opted tool along with its capability to evaluate large sample size and complex structures will suffice. - For readers there is very less visibility of the detailed measurement model results (instrument's reliability, validity, correlation, coefficient of determination, multi-collinearity and more). The less evidence of the said results and associated discussion reduces the support for the structural model results of the current research. - Overall, material and method sections need to be revised for their comprehension and filling in the above mentioned gaps. This will result significantly increased credibility of the current research. Discussion: Expansion of discussion in terms of theoretical and practical implications of the present research needs to be done. ********** 7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files. If you choose “no”, your identity will remain anonymous but your review may still be made public. Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy. Reviewer #1: No Reviewer #3: No ********** [NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files.] While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool, https://pacev2.apexcovantage.com/. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email PLOS at figures@plos.org. Please note that Supporting Information files do not need this step. |
| Revision 2 |
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Does Grit Protect Against the Adverse Effects of Depression on Academic Achievement? PONE-D-21-39237R2 Dear Dr. Collins, We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements. Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication. An invoice for payment will follow shortly after the formal acceptance. To ensure an efficient process, please log into Editorial Manager at http://www.editorialmanager.com/pone/, click the 'Update My Information' link at the top of the page, and double check that your user information is up-to-date. If you have any billing related questions, please contact our Author Billing department directly at authorbilling@plos.org. If your institution or institutions have a press office, please notify them about your upcoming paper to help maximize its impact. If they’ll be preparing press materials, please inform our press team as soon as possible -- no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org. Kind regards, Ali B. Mahmoud, Ph.D. Academic Editor PLOS ONE Additional Editor Comments (optional): Reviewers' comments: Reviewer's Responses to Questions Comments to the Author 1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation. Reviewer #3: All comments have been addressed ********** 2. Is the manuscript technically sound, and do the data support the conclusions? The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented. Reviewer #3: Yes ********** 3. Has the statistical analysis been performed appropriately and rigorously? Reviewer #3: Yes ********** 4. Have the authors made all data underlying the findings in their manuscript fully available? The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified. Reviewer #3: Yes ********** 5. Is the manuscript presented in an intelligible fashion and written in standard English? PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here. Reviewer #3: Yes ********** 6. Review Comments to the Author Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters) Reviewer #3: (No Response) ********** 7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files. If you choose “no”, your identity will remain anonymous but your review may still be made public. Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy. Reviewer #3: No ********** |
| Formally Accepted |
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PONE-D-21-39237R2 Does grit protect against the adverse effects of depression on academic achievement? Dear Dr. Collins: I'm pleased to inform you that your manuscript has been deemed suitable for publication in PLOS ONE. Congratulations! Your manuscript is now with our production department. If your institution or institutions have a press office, please let them know about your upcoming paper now to help maximize its impact. If they'll be preparing press materials, please inform our press team within the next 48 hours. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information please contact onepress@plos.org. If we can help with anything else, please email us at plosone@plos.org. Thank you for submitting your work to PLOS ONE and supporting open access. Kind regards, PLOS ONE Editorial Office Staff on behalf of Dr. Ali B. Mahmoud Academic Editor PLOS ONE |
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