PONE-D-22-24662Quality of Life, self-reported outcomes and impact of education in persons with moderate and severe Hemophilia A: an integrated perspective from a Latin American countryPLOS ONE

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“Yes, this study was sponsored by Bayer S.A. Colombia.”

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“This study and manuscript development was fully funded by Bayer. The study team wish to extend a special thanks to the “Liga Antioqueña de Hemofilia” for their support in coordinating and conducting the Hemophilia Patient Bootcamp, and to the study participants who provided valuable insight into their experience with the disease and its treatment. The authors would also like to acknowledge the support of Dr. Mark Skinner and the PROBE study for the review of the manuscript. We thank Dr. Ana Maria Perez who provided english editing and review.”

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“Yes, this study was sponsored by Bayer S.A. Colombia.”

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“Juan Satizabal, Ximena Salazar, Diana Benavides and Raul Gamarra are employees of IPSOS Napoleon Franco S.A., the outcomes research consultancy commissioned by Bayer to conduct the qualitative analysis of this study. Liliana Torres, Oscar Peñuela, Maria del Rosario Forero, Marcela Rivera, David Vizcaya and Juan-Sebastian Franco are employees of Bayer. All authors have no further conflicts to disclose.”

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Additional Editor Comments:

This is a well written and important study. Please see below the comments to be addressed. Please answer them very carefully, particularly the topic of self-infusion.

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

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Reviewer #1: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: N/A

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Reviewer #1: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

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Reviewer #1: Yes

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5. Review Comments to the Author

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Reviewer #1: Thank you for submitting this manuscript for consideration, it offers an important insight into the care and treatment of people with haemophilia in South America.

There are a couple of issues that it would be helpful to resolve before the manuscript is published.

1. The English is very good, but there are occasions where the sentence construction isn't quite right. There are also a small but frequent number of text errors which should be addressed. It would benefit the manuscript for you to have it reviewed by a language/copy editing service if possible.

2. You have mentioned the relatively small number of participants who were able to self infuse but have not discussed this further. It would be interesting and would benefit the paper if you were to discuss this issue further, including why there are so few. what are the barriers, and how self infusion rates might be improved. It would also be interesting to see if there were any differences between the QoL of those who were able to self infuse, those who were on Prophylaxis administered by others and those who were on on demand etc.

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Reviewer #1: No

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Quality of life, self-reported outcomes and impact of education among people with moderate and severe hemophilia A: An integrated perspective from a Latin American country

PONE-D-22-24662R1

Dear Dr. Franco,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

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Kind regards,

Wolfgang Miesbach, MD

Academic Editor

PLOS ONE