PONE-D-23-16775Anti SARS-CoV-2 Antibody Kinetics up to 6 months of follow-up: Result from a Nation-wide Population-based, Age Stratified Sero-Epidemiological Prospective Cohort Study in IndiaPLOS ONE

Dear Dr. Misra,

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Reviewers' comments:

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Reviewer #1: Yes

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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5. Review Comments to the Author

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Reviewer #1: It is a well conducted multi centric study to know the change in antibody prevalence.

The aim of the study was: Therefore, we aimed to assess the change in antibody prevalence and its kinetics in a closed cohort over six months across the country in different sub-population in India.

The authors have concluded that: There is a further need for study for longer follow-up and finding actual protection from subsequent infection.

A clarification is required that did the authors assess any protection from subsequent infection in their study? If it is not assessed then this conclusion needs to be deleted.

Reviewer #2: 1) It would be appropriate if the results may be presented with respect to the IgM and IgG antibody prevalence for each site.

2) Authors to mention in the manuscript whether the 3 rounds of sample collection are from the same subjects or different people in the text, as the prevalence rate difference at various sites may be due to different times of sample collection, then the site does not have any relevance.

3) The data may be represented in more precise manner and the repeated data presentation in different forms without any new information may be avoided.

4) The reason for overlapping of sample collection during 2nd and 3rd rounds may be discussed in manuscript.

5) The manuscript may be improved by critically thinking the importance and context in which the findings stand for scientific community.

6) the manuscript may be written with description of the context specific results along with some insight on some population indicators like indigenous, migrated, work profile etc.

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Reviewer #1: No

Reviewer #2: Yes: Dr. Suresh Yadav

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Submitted filename: Reveiwer comments.docx

Anti SARS-CoV-2 Antibody Kinetics up to 6 months of follow-up: Result from a Nation-wide Population-based, Age Stratified Sero-Epidemiological Prospective Cohort Study in India

PONE-D-23-16775R1

Dear Dr. Misra,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

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Kind regards,

Yury E Khudyakov, PhD

Academic Editor

PLOS ONE

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