PONE-D-22-22860EXPLORING REGIONAL DISPARITIES IN LUNG CANCER MORTALITY IN A BRAZILIAN STATE: A CROSS-SECTIONAL ECOLOGICAL STUDYPLOS ONE

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Academic Editor

PLOS ONE

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Additional Editor Comments:

Dear Editor and authors,

Thank you for the opportunity to review this manuscript. I am grateful for the invitation.

After careful consideration, I feel the manuscript explores a very important topic and we invite you to submit a revised version, on specific issues of the manuscript that addresses the points raised during the review process. The objective, the design and the results of this study are relevant.

Kind regards,

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

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3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: No

Reviewer #2: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: The paper explores the relationship between lung cancer mortality and some variables, regarding a brazilian region. The procedures and techniques used seem sound and the conclusion follows from the results´ analysis. It is important to make a final revision of the text and to make the whole set of data available to the audience putting all of it in one place (in the web).

Reviewer #2: The study presents an interesting spacial description and analysis of lung cancer cases in Parana. This kind of study is important to better destine public policies in the state. However, I miss some things in the discussion: what are the study strengths? And what are the health implications?

What the managers can do with this information? For me, this study it's more important for this public, so they need to understand what is the scenario and what they can do.

Minor points

The title is duplicated in the submission.

Figures 2 and 3: The caption should be below the figure, not in the title. Figure 3 needs a title. The sentence there is the caption.

Line 302-304: Why these areas? Some people that will ready your work don't know Parana. I miss some explanation or hypothesis for this. It's because there are rural areas? Or because tobacco production occurs in these regions?

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Reviewer #1: No

Reviewer #2: Yes: Luana Lara Rocha

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EXPLORING REGIONAL DISPARITIES IN LUNG CANCER MORTALITY IN A BRAZILIAN STATE: A CROSS-SECTIONAL ECOLOGICAL STUDY

PONE-D-22-22860R1

Dear,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

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Kind regards,

Fernanda Penido Matozinhos, Ph.D

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Dear authors, the manuscript explores a very important topic and it has technical rigor.

Thank you for submitting your manuscript to PLOS ONE and making substantial changes in order to improve the manuscript. I congratulate the authors for the work developed. The objective is relevant and the results are of interest for a wide range of potential readers. I recommend its publication.

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

Reviewer #2: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: (No Response)

Reviewer #2: Yes

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3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: (No Response)

Reviewer #2: Yes

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4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: (No Response)

Reviewer #2: Yes

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5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: (No Response)

Reviewer #2: Yes

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6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: (No Response)

Reviewer #2: (No Response)

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7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: No

Reviewer #2: No

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