PONE-D-22-18402CT Radiomics for Differentiating Fat Poor Angiomyolipoma from Clear Cell Renal Cell Carcinoma: Systematic Review and Meta-Analysis.PLOS ONE

Dear Dr. Malayeri,

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Academic Editor

PLOS ONE

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3. The proposed approach each stage is not discussed in details, nor each stage is interlink appropriately and the discussion is very poor. Please revise it carefully.

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6. The following recent studies on should be discussed in related work;

Data hiding technique in steganography for information security using number theory, 2019

MedDeblur: Medical Image Deblurring with Residual Dense Spatial-Asymmetric Attention, 2022

Stress Estimation Model for the Sustainable Health of Cancer Patients, 2022

Publishing and interlinking covid-19 data using linked open data principles: toward effective healthcare planning and decision-making, 2022

Image authenticity detection using DWT and circular block-based LTrP features, 2019

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Reviewers' comments:

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Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

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3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: No

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

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Reviewer #1: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: 1. A common radiologic dilemma is still not avoided for CT imaging to differentiate fat-poor angiomyolipomas (fp-AMLs) from clear cell renal cell carcinomas (ccRCCs) due to the limitation of density of CT images. CT radiomics may improve to present the renal mass characteristics on basis of CT images, and many studies proved that it is a good tool in detecting fp-AMLs from RCCs. This article about the systematic Review and Meta-Analysis of CT Radiomics for Differentiating fp-AMLs from ccRCCs will be benifit to acknowledge the role of CT radiomics.

2. Radiomics is still being a hot topic because it is a promising and powerful addition to the diagnostic armamentarium, and the limitations is evident in the design and execution of the studies and these limit its translation into clinical practice. The distinctive characteristics of CT radiomics are not deep analyzed and not widely acknowleged. This article did not present the different signs of CT radiomics in detail for RCCs and fp-AMLs, and the cited articles are small.

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Reviewer #1: No

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CT Radiomics for Differentiating Fat Poor Angiomyolipoma from Clear Cell Renal Cell Carcinoma: Systematic Review and Meta-Analysis.

PONE-D-22-18402R1

Dear Dr. Malayeri,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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Kind regards,

Zahid Mehmood, PhD

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Accept in current form as authors have addressed all reviewer comments in the revised manuscript.

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

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5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: (No Response)

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7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: No

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