PONE-D-22-33473Impact of end-stage knee osteoarthritis on perceived physical function and quality of life in the Middle East: A descriptive study in JordanPLOS ONE

Dear Dr. Abujaber,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

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ACADEMIC EDITOR:Revise according to the reviewers' comments and clearly highlight potential limitations for this study and future directions. 

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Aqeel M Alenazi

Academic Editor

PLOS ONE

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Additional Editor Comments:

Revise according to the reviewers' comments and clearly highlight potential limitations for this study and future directions.

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Partly

Reviewer #3: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: N/A

Reviewer #3: Yes

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3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: No

Reviewer #2: No

Reviewer #3: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: No

Reviewer #3: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: Nice work! I would suggest to mention about how the Knee Injury and Osteoarthritis Outcome Score (KOOS) was translated to Arabic. Having only 4 male out of 52 participants is not optimal. Also, I am not sure if you calculated the power analysis. There were no justification about why you used that normalization method for KOOS.

Reviewer #2: İn line 97-101

Jordanians have cultural habits that involve cross-sitting and kneeling for lengthy periods during the day, most of them are Arab Muslims who pray five times a day, and this religious activity includes kneeling, knee bending, and

frequent squatting which might exacerbate the loads on the knees. They also tend to postpone surgical intervention decisions. ( This sentence is just your opinion. Not well-intentioned also. The literature says the opposite. You haven't even looked at the literature. You can look this study, Yılmaz, S., Kart-Köseoglu, H., Guler, O., & Yucel, E. (2008). Effect of prayer on osteoarthritis and osteoporosis. Rheumatology International, 28, 429-436. )

Reviewer #3: 1. Author need to revised the title as in the title it is written middle east, whereas study has only included the participants from only one hospital with sample of 52 only. So this can't be generalize to whole middle east.

2. It will be good to add end-stage knee OA in the short title.

3. It will be good to remove KOOS in the keyword or write the full term.

4. see the referencing style.

5. Result: Line 198-200: Doesn't make clear sense. Write it clearly.

6. Limitation: The major limitation of the study is limited sample size and majority are female. So, the findings can't be generalize to larger population. Although OA knee is common among female population.

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Reviewer #1: No

Reviewer #2: Yes: Esedullah AKARAS

Reviewer #3: Yes: Bishnu Dutta Acharya

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Impact of end-stage knee osteoarthritis on perceived physical function and quality of life: A descriptive study from Jordan

PONE-D-22-33473R1

Dear Dr. Abujaber,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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If your institution or institutions have a press office, please notify them about your upcoming paper to help maximize its impact. If they’ll be preparing press materials, please inform our press team as soon as possible -- no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org.

Kind regards,

Aqeel M Alenazi

Academic Editor

PLOS ONE

Additional Editor Comments (optional):  The authors have addressed all the comments suggested by the reviewers. The concern regarding sample size has been sufficiently addressed in the limitations section of the manuscript.

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #2: All comments have been addressed

Reviewer #3: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #2: Yes

Reviewer #3: Partly

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3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #2: N/A

Reviewer #3: Yes

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4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #2: Yes

Reviewer #3: Yes

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5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #2: Yes

Reviewer #3: Yes

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6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #2: All comments have been addressed.

Reviewer #3: The author has written the paper nicely however, to consider for the publication there should be at least 100 sample size so the findings of study can be generalized.

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7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #2: Yes: Esedullah AKARAS

Reviewer #3: Yes: Bishnu Dutta Acharya

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