PONE-D-21-38646Wave-controlled aliasing in parallel imaging (Wave-CAIPI): Accelerating speed for the MRI-based diagnosis of enhancing intracranial lesions compared to magnetization-prepared gradient echoPLOS ONE

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This research was supported by the Chung-Ang University Research Grants in 2021.”

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Your manuscript was reviewed by an expert in diagnostic radiology. Reviewer found the study to be a complementary to previous research and it has a broad interest. I agree with the reviewer and suggest a minor revision for the manuscript.

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Reviewers' comments:

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Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

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3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

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Reviewer #1: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: This is a well-conducted study evaluating an ultrafast MRI technique, wave-CAIPI, against conventional post-contrast imaging using the MPRAGE sequence. The authors demonstrate high agreement for the detection and diagnosis of enhancing lesions using wave-CAIPI MPRAGE as compared to conventional MPRAGE in half the scan time. The manuscript is clearly written, and the text is supported by appropriately chosen tables and figures. This work complements recently published work on the clinical validation of the wave-CAIPI technique and will be of broad interest to clinicians and researchers in neuroimaging.

Abstract: The motivation and purpose are clearly defined, and the conclusion is consistent with the findings of the paper.

Introduction: The introduction provides a good overview of the problem and provides appropriate motivation and context for the current comparative evaluation of post-contrast wave-CAIPI MPRAGE. It would be helpful to cite recently published work evaluating post-contrast wave-CAIPI MPRAGE for detection of enhancing lesions, which the results of the current manuscript affirm: Filho ALMG et al. Eur Radiol. 2022 Dec 2;1-11.

Methods:

- Image Acquisition: Was the order of wave-CAIPI and conventional MPRAGE imaging randomized after contrast injection? The time elapsed between injection of contrast and imaging may influence the conspicuity of enhancing lesions, particularly on the MPRAGE sequence. A sentence clarifying the order of the sequences should be included in the methods, and a discussion of the order and its impact on the results should be included in the discussion.

Results:

- Were any other artifacts other than motion (e.g., flow-related artifact) evaluated for? Could these artifacts contribute to false positives for enhancing lesions?

- Otherwise, thoroughly described and transparently documented in the tables and figures.

Discussion:

- The authors should provide a comprehensive discussion of other wave-CAIPI papers that have been published demonstrating the equivalent evaluation of enhancing lesions using wave-CAIPI T1 SPACE (see: Filho ALMG et al. J Neuroimaging. 2021 Sep;31(5):893-901; Filho ALMG et al. Front Neurol. 2020 Oct 27;11:587327) and the evaluation of demyelinating and white matter lesions using wave-CAIPI FLAIR imaging (see: Ngamsombat C et al. AJNR Am J Neuroradiol. 2021 Sep;42(9):1584-1590).

Conclusion:

- Concise and highlights the main conclusions of this work.

References: Aside from the additions suggested above, appropriate as cited.

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Reviewer #1: No

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Wave-controlled aliasing in parallel imaging (Wave-CAIPI) : Accelerati ng speed for the MRI-based diagnosis of enhancing intracranial lesions compared to magnetization-prepared gradient echo

PONE-D-21-38646R1

Dear Dr. Yim,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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Kind regards,

Cem M. Deniz

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Congratulations on the acceptance of your manuscript.

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

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5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: The authors have thoroughly addressed all of my review comments. I have no further edits to suggest. I commend the authors on a job well done.

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7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: No

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