PONE-D-22-31389Feature Selection for High Dimensional Microarray Gene Expression Data via Weighted  Signal to Noise RatioPLOS ONE

Dear Dr. Khan,

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Muhammad Fazal Ijaz

Academic Editor

PLOS ONE

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Partly

Reviewer #2: Yes

Reviewer #3: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: N/A

Reviewer #3: I Don't Know

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3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: The overall impression of the technical contribution of the current study is reasonable. However, the Authors may consider doing necessary amendments to the manuscript for better comprehensibility of the study.

Reviewer #2: Abstract must be rewritten with objectives included and mention accuracy rate of performance.

Write the problem statement.

Mention the contributions made in the paper.

Discuss the Related work.

Justify your approach with the help of performance parameters.

Include Table of Comparison with the state-of-the-art literature.

Proposed method (WSV − Sn) needs to be defined and called it with a precise name.

Reviewer #3: In this paper, authors presented a novel feature selection method by exploiting the weights of features based on support vectors and signal to noise ratio. However, there are some limitations that must be addressed as follows.

1. The abstract is not attractive. Some sentences in abstract should be modified to make it more attractive for readers. In addition, the repetition should be removed (see the word ‘the proposed method’)

2. In Introduction section, it is difficult to understand the novelty of the presented research work. This section should be modified carefully. In addition, the main contribution should be presented in the form of bullets.

3. The authors should discuss the existing work properly. In addition, the following works should be discussed: A smart healthcare monitoring system for heart disease prediction based on ensemble deep learning and feature fusion, An intelligent healthcare monitoring framework using wearable sensors and social networking data, Artificial intelligence in disease diagnosis: a systematic literature review, synthesizing framework and future research agenda, A tri-stage wrapper-filter feature selection framework for disease classification

4. Figures are blurred, their quality should be improved.

5. Captions of the Figures not self-explanatory. The caption of figures should be self-explanatory, and clearly explaining the figure. Extend the description of the mentioned figures to make them self-explanatory.

6. More details should be included in future work.

7. The whole manuscript should be thoroughly revised in order to improve its English.

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Reviewer #1: No

Reviewer #2: Yes: Dr. Jana Shafi

Reviewer #3: No

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Feature Selection for High Dimensional Microarray Gene Expression Data via Weighted  Signal to Noise Ratio

PONE-D-22-31389R1

Dear Dr. Khan,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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If your institution or institutions have a press office, please notify them about your upcoming paper to help maximize its impact. If they’ll be preparing press materials, please inform our press team as soon as possible -- no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org.

Kind regards,

Muhammad Fazal Ijaz

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

Reviewer #3: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #3: Yes

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3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #3: Yes

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4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #3: Yes

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5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #3: Yes

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6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: The authors have addressed all the recommendations of the reviewers in a reasonable manner, manuscript in the current from may be considered for the further phase of editorial process.

Reviewer #3: The authors have addressed my all comments. I have no further comments. Therefore, this paper can be accepted in its present form.

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7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: No

Reviewer #3: No

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