PONE-D-22-28883A scoping review of medication self-management interventions for persons with traumatic spinal cord injuryPLOS ONE

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: N/A

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3. Have the authors made all data underlying the findings in their manuscript fully available?

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Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: Thank you for shedding light on this topic. There is a dearth of literation integrating the patient and caregiver voices, with the exception of some collaborative care model data. This paper has a remarkable potential to bring this issue into the mainstream through PLOS, but I suggest a minor revision.

Line 220-222

Consecutive sentences “All of the articles reported the sex of the participants, and all included a higher proportion of male participants than female [32-34]. None reported the participants’ gender.” may be misconstrued to be internally inconsistent. Consider re-writing for text flow.

Overall, the findings of this scoping review paper would be valuable to the discipline of collaborative care, hospice, and Bio-ethics, advocating for enhanced patient autonomy.

Reviewer #2: The article is an interesting read. Assimilating the available articles and comparing the three literatures that offer tools for self-management of medication was done tactfully, carefully separating the outcomes- per behavioral outcomes, learning outcomes and clinical outcomes were thoughtful.

The only recommendation would be modifying the title: The scoping review of medication self-management, provided an initial thought to me- if patients with SCI struggled with self-medication challenges, only to realize after reading the article that they struggle managing their polypharmacy/medications independently without appropriate tools.

One recommendation for the title could be- Scoping Review of Self-Management Intervention tools utilized for treatment of persons with Traumatic Spinal Cord Injury.

Reviewer #3: The manuscript by Cadel et al. studies the important topic of self-management interventions in spinal cord injury (SCI) considering the chronicity of the condition, the short- and long-term impact on general health, and the quality of life of the patient and their caregivers.

Strengths of the paper:

- The abstract describes the findings of the study as well as suggestions on what can be done.

- The introduction to the article is well organized.

- Methods and results are clearly described.

- The discussion and conclusion further elaborate on the challenges in the treatment of patients with SCI and strategies for mitigating these challenges.

Some recommendations:

- As the authors have pointed out, self-management is not consistently defined. It may be worth adding a brief commentary on the findings of other publications to develop a model for self-management for SCI, for example, by Munce et al. (Munce, S.E.P., Webster, F., Fehlings, M.G. et al. Meaning of self-management from the perspective of individuals with traumatic spinal cord injury, their caregivers, and acute care and rehabilitation managers: an opportunity for improved care delivery. BMC Neurol 16, 11).

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Reviewer #1: No

Reviewer #2: No

Reviewer #3: No

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A scoping review of medication self-management intervention tools to support persons with traumatic spinal cord injury

PONE-D-22-28883R1

Dear Dr. Guilcher,   

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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Kind regards,

Saeed Ahmed, MD

Academic Editor

PLOS ONE

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

Reviewer #3: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #3: Yes

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3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #3: (No Response)

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4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #3: Yes

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5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #3: Yes

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