PONE-D-22-28909Drug-related problems in hypertension and gestational diabetes mellitus: a hospital cohortPLOS ONE

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Kind regards,

Nnabuike Chibuoke Ngene, Dip HIV Med; MMed(FamMed); FCOG; MMed(O&G); Ph.D

Academic Editor

PLOS ONE

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Reviewer #1: Yes

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Thank you for asking me to review this article. The article is not only interesting but quite informative as it appears to bring to our consciousness some of the obscure factors affecting drug effectiveness in high risk pregnancy. The methodology is appropriate for the research objectives. The use of a single institution for data collection seems to be a major concern, but this can be addressed with a multi centre study in future. I would recommend this article for publication

Reviewer #2: In the abstract, the following, the univariate analysis is not mentioned. Also Insulin and methyldopa are not pharmacological classes. Please check and correct

52 addition to descriptive statistics, a multivariate logistic regression model was employed to

53 determine the factors associated with the DRPs. Results: A total of 873 DRPs were identified.

54 The most frequent DRPs were related to therapeutic ineffectiveness (72.2%) and occurrence of

55 adverse events (27.0%) and the main pharmacological classes involved were insulins and

56 methyldopa.

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Reviewer #1: Yes: Ekwuazi Kingsley Emeka

Reviewer #2: Yes: Modupe Olufunmilayo Ogunrombi

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Drug-related problems in hypertension and gestational diabetes mellitus: a hospital cohort

PONE-D-22-28909R1

Dear Dr. Martins,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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Kind regards,

Nnabuike Chibuoke Ngene, Dip HIV Med; MMed(FamMed); FCOG; MMed(O&G); Ph.D

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #2: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #2: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #2: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #2: Yes

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5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #2: Yes

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #2: The comments made earlier in the review I submitted on the manuscript titled: "Drug-related problems in hypertension and gestational diabetes mellitus: a hospital cohort" have now been addressed by the authors in the resubmission and the manuscript can now be accepted for publication.

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7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #2: Yes: Modupe Olufunmilayo Ogunrombi

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