PONE-D-22-25782When Performance is not Enough - A Multidisciplinary View on Clinical Decision SupportPLOS ONE

Dear Dr. Roller,

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PLOS ONE

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Partly

Reviewer #2: No

Reviewer #3: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: N/A

Reviewer #2: No

Reviewer #3: I Don't Know

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3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: No

Reviewer #3: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: No

Reviewer #2: No

Reviewer #3: No

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: -Related work needs to be updated more followed by adding references.

-It is recommended to add a table of past work on clinical decision support.

-Improve the quality of figure1.

-Illustrate your clinical decision support model as figure 2.

-Brief on field of nephrology.

-Justify why authors chose this area of Nephrology while many areas also require urgent clinical decision support.

-The statement in the paper required refrences to quote "we present here was developed in a project by some of the

authors of this paper, namely the computer scientists and the clinical experts"

-Contrast your work with the existing or recent works furnished and prove your model to be most significant.

-Showcase your Risk prediction model as data flow diagram.

-Mention the ability of your model to target other areas in the scope for future work.

Reviewer #2: 1. Abstract is too short

2. Introduction need to be improved more add some lines about the motivation about the field of study

3. add major contribution points at the end of the introduction

4. Add literature study section after introduction and cite at least 10 papers also add one table which need to have limitation of the existing field of study.

5. A case study need to be explained more

6. Explain more figure 1

7. Table 1 need to be explained more in detail

8. Add methodology section also work on some more machine learning classifiers

9. Related work is too short

10. Add future directions separate section

11. Add some proper experimental results

12. Overall paper English is too much poor try to improve the language

Reviewer #3: In this paper, authors presented a multidisciplinary view on machine learning in medical decision support systems. However, there are some limitations that must be addressed as follows.

1. This work is not presented correctly. The standard format of the research article should be used: abstract, introduction, related work, methodology, results, and conclusion.

2. The abstract is very short and not attractive. The novelty should be clearly discussed. In addition, In the last lines of abstract, the authors should discuss results and highlight in what %age and in what parameters the proposed methodology is better as compared to existing techniques and what is the overall analysis of proposed methodology.

3. In Introduction section, it is difficult to understand the novelty of the presented research work. This section should be modified carefully. In addition, the main contribution should be presented in the form of bullets.

4. More related work should be included about clinical decision support system (‘An intelligent healthcare monitoring framework using wearable sensors and social networking data’, ‘Automatic detection of Alzheimer’s disease progression: An efficient information fusion approach with heterogeneous ensemble classifiers’, ‘ANAF-IoMT: A Novel Architectural Framework for IoMT-Enabled Smart Healthcare System by Enhancing Security Based on RECC-VC’,’ Fine-Tuned DenseNet-169 for Breast Cancer Metastasis Prediction Using Fast AI and 1-Cycle Policy’). In addition, In the last lines of Literature review, highlight what overall technical gaps are observed in existing works that led to the design of proposed methodology.

5. Captions of the Figures and tables not self-explanatory. These captions should be self-explanatory, and clearly explaining the figure and table. Extend the description of the mentioned figures and tables to make them self-explanatory.

6. Figure 1 is blurred, its quality should be improved.

7. Data analysis section should be extended by including more details.

8. The conclusion section should be revised. In addition, the future work should be included.

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Reviewer #1: Yes: Dr.Jana Shafi

Reviewer #2: No

Reviewer #3: No

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When Performance is not Enough - A Multidisciplinary View on Clinical Decision Support

PONE-D-22-25782R1

Dear Dr. Roller,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

An invoice for payment will follow shortly after the formal acceptance. To ensure an efficient process, please log into Editorial Manager at http://www.editorialmanager.com/pone/, click the 'Update My Information' link at the top of the page, and double check that your user information is up-to-date. If you have any billing related questions, please contact our Author Billing department directly at authorbilling@plos.org.

If your institution or institutions have a press office, please notify them about your upcoming paper to help maximize its impact. If they’ll be preparing press materials, please inform our press team as soon as possible -- no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org.

Kind regards,

Muhammad Fazal Ijaz

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #3: (No Response)

Reviewer #4: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #3: (No Response)

Reviewer #4: Yes

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3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #3: (No Response)

Reviewer #4: Yes

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4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #3: (No Response)

Reviewer #4: Yes

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5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #3: (No Response)

Reviewer #4: Yes

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6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #3: The authors have addressed my all comments. I have no further comments. Therefore, this paper can be accepted in its present form.

Reviewer #4: Authors have addressed the recommendations of the reviewers in a reasonable manner. Manuscript in the current form may be processed to next phase of the editorial process.

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7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #3: No

Reviewer #4: No

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