PONE-D-22-29908Development of a digital imaging analysis system to evaluate the treatment response in superficial infantile hemangiomasPLOS ONE

Dear Dr. Liu,

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Fahmi Hussein Kakamad

Academic Editor

PLOS ONE

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Reviewers' comments:

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Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Partly

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

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3. Have the authors made all data underlying the findings in their manuscript fully available?

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Reviewer #1: Yes

Reviewer #2: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

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Reviewer #1: Yes

Reviewer #2: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: -A thorough English language revision is required.

-What is RGB appearing in the abstract, when an abbreviation appears for the first time, it should be defined.

-How the system helps in the clinical practice?! the authors should clearly address the benefit of this system

-Reference number 18,20,21 and 22 should be rewritten to become searchable reference

Reviewer #2: � The manuscript needs to be refined by a native speaker.

Introduction

1. Line 41. references are not listed in order of appearance in the text

2. Line 42. It is not appropriate to begin a sentence with an abbreviation. It must be corrected.

3. Line 66-96. The source from where you received this sentence should be cited.

4. The introduction part is typically very lengthy and needs to be brief.

Method

1. The method section has been well written and organized

2. Image acquisition:

Line 95. Please do not use abbreviation in the method section or at least write the complete word once before using abbreviation

3. Data acquisition: It is best to write inclusion criteria and exclusion criteria under different subheadings.

4. Ethical consideration: Ethics approval Please provide the ethics approval no.

Reference

The DOI should include references 4, 18, 20, 21, and 22.

Figure 2. A, B, C and D must be placed to the top left of each section of the figure, NOT overlapping the image

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Reviewer #1: No

Reviewer #2: No

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Submitted filename: Comments.docx

Development of a digital imaging analysis system to evaluate the treatment response in superficial infantile hemangiomas

PONE-D-22-29908R1

Dear Dr. Liu,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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Kind regards,

Fahmi Hussein Kakamad

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments: