PONE-D-22-20121lncRNA-TCONS_00008552 expression in patients with pulmonary arterial hypertension due to congenital heart diseasePLOS ONE

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This work was financially supported by the National Natural Science Foundation of China (82170325), grant recipient (Bin Liao); the Scientific Research Project of Southwest Medical University (2021ZKQN100); grant recipient (Qi Yang); the Scientific Research Project of Southwest Medical University (2021ZKMSO21), grant recipient (Mingbin Deng)

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This work was financially supported by the National Natural Science Foundation of China (82170325), grant recipient (Bin Liao); the Scientific Research Project of Southwest Medical University (2021ZKQN100); grant recipient (Qi Yang); the Scientific Research Project of Southwest Medical University (2021ZKMSO21), grant recipient (Mingbin Deng)

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Reviewers' comments:

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Reviewer #1: Yes

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Overall, this is an excellent and thorough manuscript. Considering that previous research has already shown a positive correlation of the expression of lncRNAs in CHD embryology in general. For example, in TOF cases without documented PAH. This manuscript is novel in identifying genes lncRNA-TCONS_00008552 and lncRNA-ENST00000433673, specific to PAH in CHD.

Reviewer #2: The methodology is correct and article is well written. No additional statistics is required. The article is intersting and clinical relevance is discussed. The statistics performed is also good. Perhaps, the future potential of the article can be written.

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Reviewer #1: Yes: Dr. Samaa Akhtar

Reviewer #2: Yes: Mark Christopher Arokiaraj

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lncRNA-TCONS_00008552 expression in patients with pulmonary arterial hypertension due to congenital heart disease

PONE-D-22-20121R1

Dear Dr. Deng,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

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Kind regards,

Laszlo Farkas, MD

Academic Editor

PLOS ONE

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