PONE-D-23-00835Construction of Model Animals to Explore Intestinal Microbiome for Detection of Breast CancerPLOS ONE

Dear Dr. Ji,

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PLOS ONE

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"Xia JI, Weiwei LI and Tianshu Cai designed this study. Xia Ji, Ruipeng Li, Xiaoyu Hu, Yufang Tian, Liqun Liu and Chenyu Zhang performed experiments, analyzed data and interpreted results. All authors wrote and approved the manuscript."

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Reviewers' comments:

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Comments to the Author

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Reviewer #1: Yes

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

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3. Have the authors made all data underlying the findings in their manuscript fully available?

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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5. Review Comments to the Author

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Reviewer #1: Reviewer Comments:

This is a well written manuscript, thanks to author. The authors adequately represent the most relevant and recent advances in the field. The objectives and the rationale of this study are clearly stated. The methods, statistical analyses, controls, sampling mechanism, and statistical reporting (e.g.,Mean +/- SD) are appropriate, rigorous, and well described. The interpretations of results and study conclusions are supported by the data. The authors have clearly emphasized the strengths of their study, but they have not clearly stated the limitations of their study.

This Manuscript should be accepted for publication.

Reviewer #2: Check grammer and discribe more about the breast cancer model and methods for generating the model for breast cancer studies.

Also explain about the way you characterise various microbes in the gut.

Over all mauscript is well written and I will acceptance of paper after minor corrections.

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Reviewer #1: No

Reviewer #2: No

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Construction of Model Animals to Explore Intestinal Microbiome for Detection of Breast Cancer

PONE-D-23-00835R1

Dear Dr. Ji,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

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Kind regards,

MUHAMMAD SHAHID RIAZ RAJOKA, Ph.D.

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

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