PONE-D-22-23006One single drug-coated balloon for all shapes/diameters? Neointimal proliferation inhibition in porcine peripheral arteriesPLOS ONE

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Additional Editor Comments:

Can the Authors please provide some discussion with regards to future plans and methodology for human testing? Please refer to Reviewer 1 comments.

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Reviewers' comments:

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: This is a well written and well conducted experimental project. The idea of long hyper-compliant balloons for drug delivery in humans as very appealing and makes logical sense. High pressure modelling is not required for drug-delivery and instead excellent vessel wall apposition is key. This can potentially be achieved with hyper-compliance balloons.

The balloon lengths used in the animals studied were 10-15cm, but in humans, one would hope that 30-40cm balloons would be feasible in order to treat the entire popliteal and superficial femoral arterial section in one go. It would be good for the authors to discuss this in the their conclusions and the plan for in human testing.

Reviewer #2: I would like to congratulate the authors for their study. Development of new devices for the treatment of peripheral arterial disease is of paramount importance. The text is well written, comprehensive without leaving any question to the scientific community. However application of such device in humans is still under investigation especially in patients with long lesions which are either stenotic or occluded with high calcific burden.

Do the authors believe that HCDCB are effective in calcified lesions where drug delivery across the arterial wall is low?

Do the authors believe that HCDCB at low pressures can fully accommodate to different diameter lesions in humans?

Pg3 line 62 Please correct vessles to vessels

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Reviewer #1: Yes: Dominic PJ Howard

Reviewer #2: No

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One single drug-coated balloon for all shapes/diameters? Neointimal proliferation inhibition in porcine peripheral arteries

PONE-D-22-23006R1

Dear Dr. Scheller,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

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Kind regards,

Athanasios Saratzis

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments: