PONE-D-22-14831The proportion of Thai postmenopausal women who would be eligible for anti-osteoporosis therapyPLOS ONE

Dear Dr. Charoenngam,

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

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Reviewer #1: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

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3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

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Reviewer #1: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: The strength of study is large sample size. The manuscript is overall well written and informative. The study was properly designed and executed. The finding can help inform treatment guidelines in Thailand. However, there are some issues that I would like to invite the authors to comment on.

1. Please clarify the define of postmenopausal in this study? How many women aged 40-50 were there? Did all of them have natural or premature/induced menopause?

2. In the methods, please describe more details about prior fractures (trauma or non-trauma)?

3. The point estimate of the proportion of Thai menopausal women who would be eligible for treatment was given (37.3%). Please provide the related confidence intervals, quantifying the potential uncertainty of the finding which would make the interpretation stronger and more convincingly.

4. The authors defined “high-risk osteopenia” (as participants with osteopenia and 10-year probability of hip fractures with BMD ≥ 3% and/or MOF with BMD ≥ 20%.), but I think the term “high risk of fracture” is more appropriate.

5. Please discuss more about the likelihood of vertebral fracture was not significantly difference between participants with and without osteoporosis

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Reviewer #1: Yes: Lan T. Ho-Pham

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The proportion of Thai postmenopausal women who would be eligible for anti-osteoporosis therapy

PONE-D-22-14831R1

Dear Dr. Charoenngam,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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Academic Editor

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Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

Reviewer #2: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

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3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

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5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: No

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6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: The authors have addressed all the issues raised. I do not have any more questions. The manuscript now is suitable to PLOS ONE.

Reviewer #2: Piyachat Chanidkul et al have done a study looking at the proportion of postmenopausal Thai women eligible for treatment for osteoporosis.

Strengths: it is a large study of 3280 women and the study is well described.

Weaknesses:

1 Using Pubmed and Scholar I found many papers about ostoporosis in Asian women and as such this paper does not contain new information.

2 The authors have just used the NOF criteria to identify women eligible for therapy. There are many studies already published with similar outcomes.

3 The authors should have used multi-regression analysis to analyze the relationship between variables.

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7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: Yes: Lan T. Ho-Pham

Reviewer #2: No

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