PONE-D-22-00761Efficacy of the therapeutic use of video games on the depressive state of stroke patients: protocol for systematic review and meta-analysis protocolPLOS ONE

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Reviewer #1: Yes

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Reviewer #1: Yes

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Reviewer #1: Yes

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Reviewer #1: Yes

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Reviewer #1: No

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Reviewer #1: The article by Gonzalez et al. covers a very relevant topic. Methods are sounds. However, I have some comments:

“The high morbidity and mortality rates associated with have led to the increasing creation of specialised units for its treatment.” The sentence lacks a word. I think “stroke”.

“Studies comparing two different types of virtual reality without an alternative group will be not include”. Inclded not include.

However, a revision by a native speaker is definetly needed. In the present form the article is not suitable for publication.

A recent review extensively discusses the use of digital therapeutics in the management of patients with chronic neurological disorders, with a specific focus on VR (PMID: 34018047). A further recente article summarize the application of telemedicine in stroke patients’ management (PMID: 33433756). They deserve to be mentioned.

In the “data sources and search strategy” section, the verb tenses are not congruent. Please, revised it.

List exclusion criteria and inclusion criteria that so scattered are not immediate.

Conclusions should be better related to the purpose of the review.

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Reviewer #1: No

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Efficacy of the therapeutic use of video games on the depressive state of stroke patients: protocol for systematic review and meta-analysis

PONE-D-22-00761R1

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

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Kind regards,

Luigi Lavorgna

Academic Editor

PLOS ONE

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