PONE-D-21-05606Comparison of compensatory shoulder movements, functionality and satisfaction in transradial amputees fitted with two prosthetic myoelectric hooksPLOS ONE

Dear Dr. BILLON-GRUMILLIER,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

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We look forward to receiving your revised manuscript.

Kind regards,

Bijan Najafi

Academic Editor

PLOS ONE

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a. FZB(EO)19Febr21: Registration done retrospectively (after enrollment of participants)

b. FZB(EO)19Febr21: borderline ethics statement (IRB not named)

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The subjects were recruited during prosthetic medical appointments usually carried out at the rehabilitation center. During the inclusion period, all persons who met the inclusion criteria were invited to participate in the study. They received all the required oral and written information. All the subjects included in the trial signed the informed consent forms.".   

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: No

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: No

Reviewer #2: Yes

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3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: No

Reviewer #2: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: A randomized crossover clinical trial was conducted which aimed to compare shoulder abduction, manual dexterity and satisfaction between two prosthetic myoelectic hooks. Evaluations on the unaffected arm served as a control. The results are unclear.

Major revision:

Testing the primary objectives with an all-inclusive linear mixed model would be superior to the analysis approach which has been taken. Mixed models offer the ability to test for differences in the effect of Greifer, Axon-Hook, and non-affected side. T-tests should not be needed. Additionally, specify the underlying covariance structure used in the mixed models and the criteria for selecting it.

Minor revisions:

1- Abstract: Replace the rho symbol with r since rho is the population correlation and r represents the estimate of rho.

2- Sample size justification:

a. Lines 137-8: Replace “average” with the standard statistical terminology of “mean”.

b. Specify that 25 represents the standard deviation.

State the statistical testing method, the alpha level, and the power.

3- Line 238-9: Specify the “customary descriptive statistics.”

4- Line 239: Possible typographical error: Qualitative variables were described by frequencies and percentages.

5- Line 247: Consider replacing the phrase, “The alpha-risk was set at 5%,” with “P-values less than 0.05 were considered statistically significant.”

6- Throughout the manuscript: Replace average with mean.

7- The p-value associated with a correlation is a test of the null hypothesis: correlation equal to zero; however, the absolute magnitude of the coefficient indicates the strength of the linear relationship between two variables. In general, the strength or correlation coefficient is the more important statistic to focus on.

Below is a table for interpreting correlation coefficients:

Coefficient (absolute value) Interpretation

0.90 - 1.0 Very Strong

0.70 - 0.89 Strong

0.40 - 0.69 Moderate

0.10 - 0.39 Weak

less than 0.10 Negligible correlation

Reviewer #2: This paper presents an interesting research study on two prosthetic myoelectric hooks. The paper provides a good introduction and background for the study conducted. Authors have clearly explained the method, procedure, data collection and analysis of the research study conducted on eight transradial amputees. The results obtained from the study have been statistically analyzed and thoroughly discussed in the paper. Also it is good that authors have mentioned study limitations and future considerations of their research work.

However, research output from this paper seems to be poor for several reasons. Those reasons and questions for authors are as follows;

1) In the paper it is not clear, why the authors have limit themselves just for 2 myoelectric prosthetic devices. Also it seems that conducting this research study limiting just for 2 devices will not provide substantial research outcome.

2) It is acceptable for having eight participants for this study. But as mentioned in the paper, majority (or some) participants had already being used one of the prosthetic devices that have been considered in this study. So it brings biased experimental output and decrease the quality of research outcome.

3) In my point of view, for comparisons like theses, just one experimental test is not enough (i.e. BBT). You can obtain results from multiple test and then thoroughly analyzed. This will bring good research outcome for the audience.

4) Lastly, it is good to consider several performance metrics, without being stuck into one performance metric (i.e. number of blocks moved within given time) or performance metric within the same aspect(i.e. performance at shoulder movements)

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Reviewer #1: No

Reviewer #2: No

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PONE-D-21-05606R1Comparison of compensatory shoulder movements, functionality and satisfaction in transradial amputees fitted with two prosthetic myoelectric hooksPLOS ONE

Dear Dr. BILLON-GRUMILLIER,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

 Please submit your revised manuscript by Jun 18 2022 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

Please include the following items when submitting your revised manuscript:

• A rebuttal letter that responds to each point raised by the academic editor and reviewer(s). You should upload this letter as a separate file labeled 'Response to Reviewers'.
• A marked-up copy of your manuscript that highlights changes made to the original version. You should upload this as a separate file labeled 'Revised Manuscript with Track Changes'.
• An unmarked version of your revised paper without tracked changes. You should upload this as a separate file labeled 'Manuscript'.

If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter.

If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: https://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols. Additionally, PLOS ONE offers an option for publishing peer-reviewed Lab Protocol articles, which describe protocols hosted on protocols.io. Read more information on sharing protocols at https://plos.org/protocols?utm_medium=editorial-emailutm_source=authorlettersutm_campaign=protocols.

We look forward to receiving your revised manuscript.

Kind regards,

Bijan Najafi

Academic Editor

PLOS ONE

Journal Requirements:

Please review your reference list to ensure that it is complete and correct. If you have cited papers that have been retracted, please include the rationale for doing so in the manuscript text, or remove these references and replace them with relevant current references. Any changes to the reference list should be mentioned in the rebuttal letter that accompanies your revised manuscript. If you need to cite a retracted article, indicate the article’s retracted status in the References list and also include a citation and full reference for the retraction notice.

Additional Editor Comments (if provided):

I apologize for the delay in the review process of your manuscript. Despite the follow-up with the initial reviewers, except one, the rest they didn't return their comments. To avoid further delay I reviewed your revision and response letter myself. I believe your revision is response to initial critiques. The reviewer 1 has some remaining but valid concerns. These concerns are minors but need to be addressed before I could recommend the acceptance of the manuscript.

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: (No Response)

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

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3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: No

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5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: Minor revisions:

1- Express the correlation coefficients and large p-values to two significant digits.

2- Line 250: Remove the redundant statement , “The threshold for statistical significance (error type I rate) was set to α=0.05.”

3- Line 244: Specify the underlying covariance structure used in the mixed models and the criteria for selecting it.

4- Since no statistical power calculation has been provided, indicate if the study was a pilot or exploratory trial. In brief, provide the rationale for why no formal statistical power justification is needed.

5- If the interaction effect is significant, provide an interpretation of the results, but do not test main effects because the tests for main effects are uninteresting in light of significant interactions. If interaction effects are non-significant, drop the interaction effects from the model and test the main effects. Determining which results to present when testing interactions is often a multi-step process.

6- Lines 323 and 326: Provide more precise p-values, instead of p0.05.

7- In the figures, replace "average" with "mean."

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7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: No

[NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files.]

While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool, https://pacev2.apexcovantage.com/. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email PLOS at figures@plos.org. Please note that Supporting Information files do not need this step.

Comparison of compensatory shoulder movements, functionality and satisfaction in transradial amputees fitted with two prosthetic myoelectric hooks

PONE-D-21-05606R2

Dear Dr. BILLON-GRUMILLIER,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

An invoice for payment will follow shortly after the formal acceptance. To ensure an efficient process, please log into Editorial Manager at http://www.editorialmanager.com/pone/, click the 'Update My Information' link at the top of the page, and double check that your user information is up-to-date. If you have any billing related questions, please contact our Author Billing department directly at authorbilling@plos.org.

If your institution or institutions have a press office, please notify them about your upcoming paper to help maximize its impact. If they’ll be preparing press materials, please inform our press team as soon as possible -- no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org.

Kind regards,

Bijan Najafi

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Thanks for addressing the remaining critiques. After reviewing your revision and response letter I believe your revision is responsive to all initial critiques and the current revision has significant scientific merit. Thus I recommend acceptance of your revision! Congratulations!

Reviewers' comments: