PONE-D-22-06890Binary cutpoint and the combined effect of systolic and diastolic blood pressure on cardiovascular disease mortality: a community-based cohort studyPLOS ONE

Dear Dr. Park,

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Tariq Jamal Siddiqi

Academic Editor

PLOS ONE

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Reviewers' comments:

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Comments to the Author

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Reviewer #1: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

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Reviewer #1: Yes

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Reviewer #1: Yes

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5. Review Comments to the Author

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Reviewer #1: The authors presented a manuscript evaluating the combined effect of systolic and diastolic blood pressure on cardiovascular disease mortality. The analysis is well done and the manuscript has been drafted in an intelligible manner. Figures and tables are presented appropriately. However, there are a few issues which need to be addressed:

1. The authors should consider adding numbers and percentages to provide a comprehensive view of the mortality and morbidity burden in the introduction.

2. Kindly mention the full form of Fig as figure, and report table citations as Table S2 instead of S2 table.

3. The authors should report the p values associated with results mentioned within the text of the manuscript.

4. Kindly ensure that all HRs are reported along with their 95% confidence intervals.

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Reviewer #1: No

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Binary cutpoint and the combined effect of systolic and diastolic blood pressure on cardiovascular disease mortality: a community-based cohort study

PONE-D-22-06890R1

Dear Dr. Park,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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Kind regards,

Tariq Jamal Siddiqi

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments: