PONE-D-21-36989Takotsubo Cardiomyopathy in Patients Suffering From Acute Non-traumatic Subarachnoid Hemorrhage - a Single Center Follow-up StudyPLOS ONE

Dear Dr. Fülesdi,

Thank you for submitting your manuscript to PLOS ONE. First of all, I deeply apologize for this long reviewing process. I was waiting for a delayed review (reviewer 2) but decided to move forward.

Your paper was reviewed by an expert in the field and myself. As shown in the reviewer's comments, your study was well performed, and paper was well written. However, numerous numbers of papers were already published on this topic. I am aware of this journal's policy (i.e., novelty and clinical significance should not be judged) but please try to add some unique features in your study. 

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We look forward to receiving your revised manuscript.

Kind regards,

Tomohiko Ai, M.D., Ph.D.

Academic Editor

PLOS ONE

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Hungarian Brain research program [grant number KTIA_13_NAP-A-II/5], the founder is the Hungarian Academy of Sciences

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Reviewers' comments:

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Comments to the Author

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The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

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Reviewer #1: Yes

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Reviewer #1: Yes

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5. Review Comments to the Author

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Reviewer #1: This single center, prospective study was well conducted, and its results (frequency, identification of risk factors, measurement of cardiac biomarkers, outcome predictability etc.) were consistent with those of previous studies. It should be noted, however, that there have been numerous studies on the clinical characteristics of SAH-induced Takotsubo cardiomyopathy, and this study is just one of them. Few novel findings were derived from this study, except that long-term echocardiographic follow-up had been conducted.

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Reviewer #1: No

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Takotsubo Cardiomyopathy in Patients Suffering From Acute Non-traumatic Subarachnoid Hemorrhage - a Single Center Follow-up Study

PONE-D-21-36989R1

Dear Dr. Fülesdi,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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Kind regards,

Tomohiko Ai, M.D., Ph.D.

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments: