PONE-D-21-31414

Prognostic significance of severe coronary microvascular dysfunction post-PCI in patients with STEMI: a systematic review and meta-analysis

PLOS ONE

Dear Dr. Barone-Rochette,

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Academic Editor

PLOS ONE

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4. We noticed you have some minor occurrence of overlapping text with the following previous publication(s), which needs to be addressed:

- https://linkinghub.elsevier.com/retrieve/pii/S1443950619313241

-https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.117.005361

- https://www.heartlungcirc.org/article/S1443-9506(19)31324-1/fulltext

- http://eprints.gla.ac.uk/118950/7/118950.pdf

In your revision ensure you cite all your sources (including your own works), and quote or rephrase any duplicated text outside the methods section. Further consideration is dependent on these concerns being addressed.

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Additional Editor Comments:

The reviewers were quite favorable on this paper after some lengthy deliberations. Please address the minor comments below in an individual fashion prior to acceptance.

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: Well-written article. I have some minor typographical/grammatical suggestions:

Non-inclusion criteria = exclusion criteria?

Trough = through?

Given we included = given the included?

they is a metric = they are?

Please check for dots and comma’s in tables

Reviewer #2: The authors described in this review and metaanalysis the prognostic impact of microcirculation damage measured invasively during STEMI. They conclude that both the IMR and the HMR, (2 quantifiable markers of damage to the microcirculation) considered qualitatively have a prognostic interest.

I have a few minor points to discuss or clarify in the introduction, method, discussion and limitations/

In the abstract please correct 2019 as a study published in 2020 was included in the metaanalyses.

Authors should justify the threshold value choosen for IMR and HMR to define severe CMVD.

Could the authors provide some data regarding the location of STEMI patients, the culprit artery? Were IMR and HMR measured on the infarted area?

Authors should discuss the use of other potential surrogates of microcirculation disease (TIMI flow, MVO for example) and acknowledge the lack of such angiographic or imaging data in the considered studies.

In the discussion the following sentenece should be referenced or removed "The

assessment of HMR is probably more challenging than that of IMR, with higher failure

rates related to unreliable doppler flow velocity tracings"

Reviewer #3: In their meta-analysis, Canu et al. aimed to conduct a systematic review of the existing literature related to the clinical implications of severe CMVD in STEMI patients. This study is well design, original and very interesting.

The main limitation is the limited number of eligible studies, but the authors emphasized this in their discussion. However, the study provides interesting insights that deserve to be published.

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Reviewer #1: No

Reviewer #2: No

Reviewer #3: No

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Prognostic significance of severe coronary microvascular dysfunction post-PCI in patients with STEMI: a systematic review and meta-analysis

PONE-D-21-31414R1

Dear Dr. Barone-Rochette,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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Kind regards,

R. Jay Widmer

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

Reviewer #3: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: (No Response)

Reviewer #3: Yes

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3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: (No Response)

Reviewer #3: I Don't Know

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4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: (No Response)

Reviewer #3: Yes

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5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: (No Response)

Reviewer #3: Yes

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6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: (No Response)

Reviewer #3: The authors have adequately addressed all the comments, thank you. This manuscript is now acceptable for publication

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7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: No

Reviewer #3: Yes: Thomas Bochaton