PONE-D-21-35333Impact and benefit-cost ratio of a program for the management of latent tuberculosis infection among refugees in a region of CanadaPLOS ONE

Dear Dr. Pépin,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

ACADEMIC EDITOR: Pls respond to the reviewers' comments.

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We look forward to receiving your revised manuscript.

Kind regards,

Gang Qin, PhD, MD

Academic Editor

PLOS ONE

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Reviewers' comments:

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Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

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Reviewer #1: Yes

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: No

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

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Reviewer #1: No

Reviewer #2: Yes

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5. Review Comments to the Author

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Reviewer #1: This is with reference to the manuscript entitled "Impact and benefit-cost ratio of a program for the management of latent tuberculosis infection among refugees in a region of Canada". The manuscript written by Jacques Pépin et al. is quiet interesting, well designed and planned for further execution. I appreciate to reply some minor comments reply from the authors which are mentioned below:

1. The authors are requested to revise the conclusion part in the Abstract portion in the above submitted Proposal.

2. Authors are requested to revise the methodology with detailed work plan describing the study population, duration of study, age of the participants, any standard proforma used for data collection, any specific exclusion criteria involved and statistical analysis used in the study as very limited information’s are available in the current submission.

3. Authors are requested to rewrite Line No. 83 and Line no. 218-220.

4. Authors are requested to add the Statistical analysis in the manuscript including the cost-utility analyses.

5. It would be better if the authors provide the flowchart of the study for better clarification as the above mentioned study is too vast and involved different duration and parameters.

6. The Author Contributions needs to be revised by the authors as these are not according to the Journal guidelines.

7. Lastly, the Authors are requested to please have a final look at the references mentioned as per the Journal guidelines.

Reviewer #2: This thesis has a good selection of topics, and has certain value in controlling the epidemic of tuberculosis. The data are detailed, the research plan is reasonable, the statistical methods are appropriate, the results are credible and the discussion is more comprehensive.

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Reviewer #1: No

Reviewer #2: No

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Attachments

Attachment

Submitted filename: PLoS One LTBI comments.docx

Impact and benefit-cost ratio of a program for the management of latent tuberculosis infection among refugees in a region of Canada

PONE-D-21-35333R1

Dear Dr. Pépin,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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Kind regards,

Gang Qin, PhD, MD

Academic Editor

PLOS ONE