PONE-D-21-40935Effect of Scanning-Aid Agents on the Scanning Accuracy in Specially Designed Metallic Models: A Laboratory StudyPLOS ONE

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Reviewer #1: Partly

Reviewer #2: Yes

Reviewer #3: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: The authors submit an article "Effect of Scanning-Aid Agents on the Scanning Accuracy in Specially Designed

Metallic Models: A Laboratory Study".

The study compares three types of sprays that are applied to the metal surface of dental prostheses and subsequently scanned with an intraoral scanner. Is there often a need in dental practice to scan metal surfaces of prostheses with an intraoral scanner? What other significant difference is there used between sprays (other than liquid type and powder type)?

The work scans the metal surface of prostheses - wouldn't it be enough to sandblast the surface to eliminate the shiny surface?

Cobalt chromium alloy or titanium alloy, is usually used in dental practice. Why did the authors use an aluminum alloy? It has no surface properties other than cobalt chromium alloy or titanium alloy?

In the article, you state that you used the I500 intraoral scanner for scanning - what technology does it scan with? Optical light? Laser? What is the accuracy and speed of scanning? Have you taken into account Trueness and Precision of the intraoral scanner itself when evaluating the data obtained?

The article is clearly written, described in detail Materials and Methods. The Trueness and Precision data are evaluated in the Results chapter.

In Conclusion, it is stated that it is better to use a liquid type spray.

This is certainly important information for dental practice, but I still miss the point, the main idea of the article. Is it a comparison of sprays or a comparison of metallic reference models (inlay, onlay, and bridge)? Why is it important for the dental technician / dentist which spray is better?

Reviewer #2: The report is well written and easy to understand. Accurate results have been achieved. The information is also accurately illustrated. The authors work with modern technologies in design. Although the SolidWorks software is not the latest version (version 2016 is listed), it is strong enough functionally.

Not as a remark, but as a recommendation:

- If possible, use institutional contact emails.

- The conclusion is too small. It should increase the size. (Also in conclusion) The most important points should be noted in separate paragraphs.

Reviewer #3: This is a fascinating study about the effect of scanning-aid agents on scanning accuracy in specially designed metallic models. Hence, the study adds to the current knowledge in this relatively new field and is definitely of clinical significance. However, it is still not clear to me the following matters as far as I read the manuscript.

This study aimed to evaluate the effect of different scanning-aid agents on the scanning performance of intraoral scanners. However, the description of ScanCure in the test group is insufficient. It is a liquid, so the authors need to describe more about it, including the ingredients. Also, there should be an explanation of how the agent from each group is applied. In what order and how many times these were applied or sprayed on the model. It is also necessary to describe how much powder was sprayed each time. The distance and angulation of the spray tip from the specimen are essential.

In the 'Acquisition of Digital Data' section, the authors say that it was difficult to obtain a reference dataset, so it was obtained using 3D design, but it is not easy to understand. First of all, HERO7106 equipment is a contact scanner known as a Coordinate Measuring Machine (CMM), not a laser scanner. As I understand it, to scan with a laser scanner, the spray must be applied no matter how industrial-level accurate scanners are, so the quality of scan data is no different from that of the test group intraoral scanner. By reflecting the dimensions of each block measured by CMM in the design data (mentioned as 3D design in the manuscript), the data was transformed into the same size as the real milled. And then, this modified data was used as reference data. I want to check whether I understood well. In addition, no matter how accurate measured values are reflected as design data, it is thought that there might still be errors. How did the authors try to overcome this part?

Tables 1 and 2 do not contain information on statistical results. In the discussion section, the authors mentioned trueness, but more analysis on precision results should follow. Although there was no statistical difference, the ScanCure group showed high precision, which should be added to the manuscript. The first sentence of the second paragraph in the discussion section says '~ VITA group had lowest RMS values,' but it seems to be the opposite. In the middle of the third paragraph, 'A hardware design of the products was sufficient to reproduce the results,' it is unclear whether the products refer to sprays/liquid, intraoral scanner, or specimen, so it is difficult to understand the intention of the authors.

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Reviewer #1: No

Reviewer #2: Yes: Professor (Associate) Tihomir Dovramadjiev PhD Eng.

Reviewer #3: No

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Effect of Scanning-Aid Agents on the Scanning Accuracy in Specially Designed Metallic Models: A Laboratory Study

PONE-D-21-40935R1

Dear Dr. Lim,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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Kind regards,

Antonio Riveiro Rodríguez, PhD

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Please, prior to publication, correct the captions of Figs. 4 & 5 as indicated by reviewer 1

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

Reviewer #2: All comments have been addressed

Reviewer #3: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: No

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5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: (No Response)

Reviewer #2: Dear authors, thank you for your opinion and activity. I accept that your arguments are correct and in accordance with the opinion of the reviewer.

Reviewer #3: The authors have amended and modified the text adequately with my suggestions for improvement and, to the best of my understanding, also proposed by the other referees. The part that still needs additional correction is that the figure legends of Figures 4 and 5 are identical. Please state that Fig. 4 indicates trueness, and Fig. 5 describes precision. I strongly recommend that this manuscript be published in PLOS ONE.

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7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

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Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: No

Reviewer #2: Yes: Professor (Assoc.) Tihomir Dovramadjiev PhD Eng.

Reviewer #3: No