Peer Review History
| Original SubmissionMay 19, 2021 |
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PONE-D-21-16309 How does it all end? Trends and disparities in health at the end of life PLOS ONE Dear Dr. Vierboom, Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process. The two reviewers, both experts in the areas of health, aging, and end of life research, have given careful consideration to your manuscript. Please address each of their thoughtful comments in your response letter. Both reviewers would like to see a better contextualization of the study in the existing literature, and more justification of some of your analytic decisions, for example: Why 6 years? Why these cause of death groupings? In addition, please address further the important limitation of the NHIS exclusion of the institutionalized population, and the selection effect that presents. Please explain what is meant in the Limitations section where it says that the newly-institutionalized NHIS respondents "remain in the sample" since the NHIS is cross-sectional. Also, please explain. the decision to exclude Hispanics and limit comparisons to non-Hispanic whites and Blacks. Please submit your revised manuscript by Aug 09 2021 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file. Please include the following items when submitting your revised manuscript:
If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter. If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: http://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols. Additionally, PLOS ONE offers an option for publishing peer-reviewed Lab Protocol articles, which describe protocols hosted on protocols.io. Read more information on sharing protocols at https://plos.org/protocols?utm_medium=editorial-email&utm_source=authorletters&utm_campaign=protocols. We look forward to receiving your revised manuscript. Kind regards, Ellen L. Idler Academic Editor PLOS ONE Journal Requirements: When submitting your revision, we need you to address these additional requirements. 1. Please ensure that your manuscript meets PLOS ONE's style requirements, including those for file naming. The PLOS ONE style templates can be found at https://journals.plos.org/plosone/s/file?id=wjVg/PLOSOne_formatting_sample_main_body.pdf and https://journals.plos.org/plosone/s/file?id=ba62/PLOSOne_formatting_sample_title_authors_affiliations.pdf 2. Please include captions for your Supporting Information files at the end of your manuscript, and update any in-text citations to match accordingly. Please see our Supporting Information guidelines for more information: http://journals.plos.org/plosone/s/supporting-information. Additional Editor Comments (if provided): [Note: HTML markup is below. Please do not edit.] Reviewers' comments: Reviewer's Responses to Questions Comments to the Author 1. Is the manuscript technically sound, and do the data support the conclusions? The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented. Reviewer #1: Partly Reviewer #2: Partly ********** 2. Has the statistical analysis been performed appropriately and rigorously? Reviewer #1: Yes Reviewer #2: Yes ********** 3. Have the authors made all data underlying the findings in their manuscript fully available? The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified. Reviewer #1: Yes Reviewer #2: Yes ********** 4. Is the manuscript presented in an intelligible fashion and written in standard English? PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here. Reviewer #1: Yes Reviewer #2: Yes ********** 5. Review Comments to the Author Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters) Reviewer #1: I indicate above that the statistical analysis has been preformed appropriately and rigorously. However, I raise concerns about how certain variables are operationalized and indicate some analysis that might be missing. Based on the analysis plan reported by the authors (and I indicate is lacking), analysis appears to have been performed appropriately and rigorously. Please see attached file for additional comments. Reviewer #2: This well-written descriptive paper provides a detailed statistical portrait of health and disability at the end of life, with careful attention to differences therein on the basis of sociodemographics (age, sex, race, education) and cause of death. The analyses are carefully done and use excellent NHIS data. Despite these strengths, the author could do more to justify their study aims and their key analytic decisions. I also encourage the author to say more about the possible influences of age vs. cohort effects, and selective survival when interpreting their results. I hope these comments are helpful to the author as they further develop this important project. 1. Why does the analysis focus on the final six years of life? Please provide a brief rationale for this decision. Other time points, such as last year of life, may align more closely with the literature on end-of-life medical expenditures, for instance. This shorter observation would help the author to better contextualize this in the literature, and link their findings to topics like expenditures. I suspect that the six-year decision was driven by sample size, but there may be other more compelling motivators. 2. More generally, the author could make a much more compelling case for the study goals. Why is this descriptive analysis helpful? What does it tell us, and how can these results advance research and policy/practice on end-of-life care? 3. PLOS is for a general readership, so more context is needed for readers who are not specialists in end-of-life topics. I would suggest a brief discussion of the strengths and weaknesses of using time-to-death measures to characterize end-of-life, and the relative strengths and weaknesses relative to measures like proxy reports and expenditure data that are other ways to characterize the end-of-life experience. 4. The section on inequalities in healthy aging, again, could do more to convey the importance and value of the research. This might be an opportune place to discuss the possibility of selective survival, such that lower SES and Blacks who survive until age 65 may show some health advantages relatives to higher SES and Whites who survive. This might be another interpretation of the seemingly counter-intuitive results whereby the least educated group appear to fare better than their more educated counterparts. 5. I would suggest using a more nuanced measure of age in the analysis, such as 65-74, 75-84, 85+. The current two category measure is quite coarse and some nuanced patterns may be concealed. 6. A minor issue. On page 13, the phrase “perceived amount of time individuals spend in unfavorable health…” is misleading. Study participants were not administered perceived life span or perceived probability of survival questions. Please re-word so that the sentence more accurately characterizes the data. 7. The analyses should raise issues of age versus cohort effects (and even touch on period effects) more directly, in the background and discussion. Even though the time period is fairly narrow, the youngest participants in 2014 and the oldest participants in 1987 represent vastly different cohorts, who have had different exposures to medications, public health interventions, assistive devices, etc. over the life course. At the very least, the limitations could say more about the inability to discern age vs cohort effects using repeated cross-sectional data. Best of luck with your revision. ********** 6. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files. If you choose “no”, your identity will remain anonymous but your review may still be made public. Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy. Reviewer #1: No Reviewer #2: No [NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files.] While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool, https://pacev2.apexcovantage.com/. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email PLOS at figures@plos.org. Please note that Supporting Information files do not need this step.
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| Revision 1 |
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PONE-D-21-16309R1How does it all end? Trends and disparities in health at the end of lifePLOS ONE Dear Dr. Vierboom, Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process. Both reviewers from the original round have reviewed the paper again and both see substantial improvement in the way the study is framed and carried out. However, both reviewers would like to see additional improvements in the writing, to bring the paper to a higher level of quality. They have made specific suggestions and provided examples that will be helpful. Please submit your revised manuscript by Mar 19 2022 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file. Please include the following items when submitting your revised manuscript:
If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: https://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols. Additionally, PLOS ONE offers an option for publishing peer-reviewed Lab Protocol articles, which describe protocols hosted on protocols.io. Read more information on sharing protocols at https://plos.org/protocols?utm_medium=editorial-email&utm_source=authorletters&utm_campaign=protocols. We look forward to receiving your revised manuscript. Kind regards, Ellen L. Idler Academic Editor PLOS ONE Journal Requirements: Please review your reference list to ensure that it is complete and correct. If you have cited papers that have been retracted, please include the rationale for doing so in the manuscript text, or remove these references and replace them with relevant current references. Any changes to the reference list should be mentioned in the rebuttal letter that accompanies your revised manuscript. If you need to cite a retracted article, indicate the article’s retracted status in the References list and also include a citation and full reference for the retraction notice. [Note: HTML markup is below. Please do not edit.] Reviewers' comments: Reviewer's Responses to Questions Comments to the Author 1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation. Reviewer #1: (No Response) Reviewer #2: All comments have been addressed ********** 2. Is the manuscript technically sound, and do the data support the conclusions? The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented. Reviewer #1: Yes Reviewer #2: Yes ********** 3. Has the statistical analysis been performed appropriately and rigorously? Reviewer #1: Yes Reviewer #2: Yes ********** 4. Have the authors made all data underlying the findings in their manuscript fully available? The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified. Reviewer #1: Yes Reviewer #2: Yes ********** 5. Is the manuscript presented in an intelligible fashion and written in standard English? PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here. Reviewer #1: No Reviewer #2: Yes ********** 6. Review Comments to the Author Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters) Reviewer #1: Thank you for the opportunity to review this revised manuscript that considers trends and disparities in end-of-life health in the U.S. The author made a good effort to address both reviewers’ (and the editor’s) comments/concerns and has strengthened the paper. Below, I have outlined some additional points to consider. Some additional editing and wordsmithing are needed and would further improve the quality of the paper. 1. The abstract could use some editing. For example, the sentence: “Time spent in fair/poor health over years 1987-2008 declined by two months, while time lived with at least one activity limitation generally remained stable from 1997-2008” is a little clunky. Time spent in fair/poor health over years 1987-2008 declined by two months compared to what? Declined by two months each year? The sentences that follow also could use some editing. The sentence: “Compared to men, women reported an IADL for 1 year longer and an ADL for 8 extra months, yet both sexes reported similar lengths of unfavorable health” also needs editing. The numbers 1 and 8 should be spelled out. Reported an IADL or ADL what? Limitation? what does the author mean by “similar lengths of unfavorable health? The way that the sentence is currently written, it is not clear what is meant here. In the next sentence, I suggest saying similar health “compared with” younger decedents instead of “to” younger decedents. Given the use of repeated cross-sectional data, I suggest using language such as “findings indicate” rather than stating the findings as if they are fact in the Discussion section of the Abstract. 2. On page 4, the author indicates the importance of examining ADL limitations (e.g., 40% of people over age 65 have at least one limitation and nearly 90% with 3+ limitations require caregiving help) but do not say why it might be important to also consider IADL limitations. They do make the case on p. 10 and may want to say something similar here on p. 4 as well. The sentence: “ADL limitations are predictive of requiring physical assistance, with roughly 40% of community-dwelling adults age 65+ with one limitation and nearly 90% with 3+ receiving caregiving help” needs editing to read more clearly. Also, physical assistance is caregiving help. 3. On p. 5, what is meant by the sentence: “Because of these simultaneously evolving environments and population characteristics, it is difficult to separate period and cohort effects.” I am not following this line of thought. I agree that the methods used in this paper (and acknowledged under Limitations) limit the ability to disentangle these effects. 4. On p. 7, instead of using wording such as, “an older study similarly constructed to this one,” consider, for example, referring to “a similar study” or “another study with a similar design,” etc. The wording here is clunky. 5. In describing the sample on p. 9 in the Methods section, information should be included regarding any exclusion criteria (e.g., living in a long-term care facility at baseline). Information should also be included here regarding the possibility that those not in long-term care at baseline could be included at follow up. 6. The literature reported in the first paragraph under the section on "Years-to death” on p. 9 in the Methods section feels out of place here. This literature should be woven into the Background section that begins on p. 3 and not here. A Methods section typically does not include a literature review. The rationale for the six years-to death timeframe can be made without including all of these citations in the Methods section. 7. On p. 12, I suggest more clearly outlining how data were pooled to conduct the varying analyses and describing the different analytic approaches in turn rather than stating: “To compare estimates across population subgroups, I pool data across years 1997-2014 (1987-2014 for SRH).” 8. Avoid using language like, “women reported either kinds of limitations for much longer” on p. 14. Again, the paper could benefit from some wordsmithing throughout to improve readability and flow and to sound more academic. 9. On p. 21, avoid using the term “elder.” The term, “older adults” is preferred by aging researchers and others. 10. When referring to Blacks and Whites, I suggest capitalizing both terms to be consistent. 11. Throughout the body of the text, “vs.” should be written out as “versus” unless included in material with parentheses. 12. On p. 11, instead of “non-Black and non-white racial/ethnic categorizations,” I might indicate that sample sizes for other racial and ethnic groups were too small to conduct any additional racial/ethnic comparisons. The language used here is a little clunky. 13. On pp. 8-11, text indicates that different sample sizes were used for different analyses (e.g., SRH vs. ADLs and IADLs as well as racial comparisons vs. other types of comparisons (e.g., educational attainment). It is not clear what the different sample sizes were for the various analyses. 14. On p. 23, The author indicates that “measuring the relative importance of cohort composition vs. period changes in the treatment of illness,” etc. would help target relevant interventions.” A brief example of how this type of analysis could inform relevant interventions might be useful here. As noted by Reviewer 2, the methods used and inability to disentangle age versus cohort versus period effects is a limitation that should be acknowledged. The author acknowledges this limitation but does not provide a concrete explanation of how/why the analysis is limited because of this constraint. 15. In the conclusion on p. 23, I suggest saying something like, “findings indicate”, etc., rather than stating results as fact. Reviewer #2: The authors have done a very thorough and responsive revision. I have just a few remaining suggestions for improvement. 1. The manuscript would benefit from a very careful copy-edit both for clarity and style. For instance, the paper opens on an awkward note. The first sentence of a manuscript should be more direct, such as “Death—and the months, days, or moments preceding it—are an important and distinct stage of the life course (Cohen-Mansfield et al. 2018)” (deleting initial clause). 2. A recent paper by Carr and Luth (2019) Annual Review of Sociology makes the case that ‘end of life’ is a distinctive life course stage. This article could be helpful for your framing of the analysis. 3. The front end of the paper could do a bit more to motivate the selection of the multiple health measures. These issues are addressed somewhat in the Discussion, but it would be helpful to foreground the fact that SRH is subjective and assessed in relation to one’s peers (who may be dying or in poor health), whereas the IADL and ADL measures are more ‘objective’ and reflect behavioral capacities. Overall, an interesting and creative paper that will make a nice contribution to the literature. ********** 7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files. If you choose “no”, your identity will remain anonymous but your review may still be made public. Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy. Reviewer #1: No Reviewer #2: No [NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files.] While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool, https://pacev2.apexcovantage.com/. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email PLOS at figures@plos.org. Please note that Supporting Information files do not need this step. |
| Revision 2 |
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How does it all end? Trends and disparities in health at the end of life PONE-D-21-16309R2 Dear Dr. Vierboom, We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements. Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication. An invoice for payment will follow shortly after the formal acceptance. To ensure an efficient process, please log into Editorial Manager at http://www.editorialmanager.com/pone/, click the 'Update My Information' link at the top of the page, and double check that your user information is up-to-date. If you have any billing related questions, please contact our Author Billing department directly at authorbilling@plos.org. If your institution or institutions have a press office, please notify them about your upcoming paper to help maximize its impact. If they’ll be preparing press materials, please inform our press team as soon as possible -- no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org. Kind regards, Ellen L. Idler Academic Editor PLOS ONE Additional Editor Comments (optional): One of the reviewers for this round is still requesting additional line-editing before final submission, for precision and more use of active voice. Please see the reviewer comments below. Reviewers' comments: Reviewer's Responses to Questions Comments to the Author 1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation. Reviewer #1: All comments have been addressed Reviewer #2: All comments have been addressed ********** 2. Is the manuscript technically sound, and do the data support the conclusions? The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented. Reviewer #1: Yes Reviewer #2: Yes ********** 3. Has the statistical analysis been performed appropriately and rigorously? Reviewer #1: Yes Reviewer #2: Yes ********** 4. Have the authors made all data underlying the findings in their manuscript fully available? The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified. Reviewer #1: Yes Reviewer #2: Yes ********** 5. Is the manuscript presented in an intelligible fashion and written in standard English? PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here. Reviewer #1: Yes Reviewer #2: Yes ********** 6. Review Comments to the Author Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters) Reviewer #1: (No Response) Reviewer #2: The authors have done a highly responsive revision, and the main methodological and conceptual concerns have been adequately addressed. I have lingering concerns about the writing, which could be more direct and precise in places. I would encourage the use of active v. passive voice where possible, and avoiding the use of vague phrases that add little to the text. For instance, rather than referring to "various populations" just specify precisely what the populations are. No need to use phrases like "in this paper" (as it is clear that the proposed analyses are being done in your paper). I encourage a very careful line-edit to enhance the clarity and conciseness of the work. Congratulations on a successful revision. ********** 7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files. If you choose “no”, your identity will remain anonymous but your review may still be made public. Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy. Reviewer #1: No Reviewer #2: No |
| Formally Accepted |
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PONE-D-21-16309R2 How does it all end? Trends and disparities in health at the end of life Dear Dr. Vierboom: I'm pleased to inform you that your manuscript has been deemed suitable for publication in PLOS ONE. Congratulations! Your manuscript is now with our production department. If your institution or institutions have a press office, please let them know about your upcoming paper now to help maximize its impact. If they'll be preparing press materials, please inform our press team within the next 48 hours. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information please contact onepress@plos.org. If we can help with anything else, please email us at plosone@plos.org. Thank you for submitting your work to PLOS ONE and supporting open access. Kind regards, PLOS ONE Editorial Office Staff on behalf of Professor Ellen L. Idler Academic Editor PLOS ONE |
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