PONE-D-21-05814

Primary care providers’ and nurses’ knowledge, attitudes, and skills regarding latent TB infection testing and treatment: A qualitative study from Rhode Island

PLOS ONE

Dear Dr. Szkwarko,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

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We look forward to receiving your revised manuscript.

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Jamie Males

Staff Editor

PLOS ONE

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"DS is partially supported by Institutional Development Award Number U54GM115677 from the National Institute of General Medical Sciences of the National Institutes of Health, which funds Advance Clinical and Translational Research (Advance-CTR https://www.brown.edu/initiatives/translational-research/home). SK is supported by NIH/NIAID under R25AI140490 – Emerging Infectious Disease Scholars (EIDS https://www.brown.edu/academics/medical/plme/current-students/enrichment-activities/research-opportunities/emerging-infectious-diseases-scholars-) Program at Brown University.

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Partly

Reviewer #2: Yes

Reviewer #3: Partly

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: N/A

Reviewer #2: N/A

Reviewer #3: No

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3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: No

Reviewer #2: Yes

Reviewer #3: No

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: Thank you for your valuable work. The following will be effective in improving your work.

1. Explaining the necessity of working with a qualitative method has not been done, while the questions can be answered with a quantitative method.

2. There is a need to edit and justify the lines.

3. What was the criterion for completing sampling and saturation in this study?

4. Which method was used to analyze the data? (With reference)

5. How is the data confidentiality criterion met?

6. Explain the inclusion and exclusion criteria.

7. Explain the questions used in the research (At least the basic questions)

8. Category tagging has happened with quantitative and pre-arranged visibility.

Reviewer #2: This a wonderful study and is aimed at promoting ending of TB disease through not missing any LTBI untreated. It is very vital that this approach to ending TB is widely known and utilised by all countries main with high TB stats.

In the background it was noted that there was no mention of LTBI treatment regimens as to be comprehensive in the clear description of the problem at hand.

There is also a need to describe the distinct difference between the PCPs and Nurses as these causes confusion as to who is who. This is given the notion that nurses are primary health care provided and this is at least what is known universally.

The article was well formatted

Reviewer #3: Manuscript Number: PONE-D-21-05814

Article Type: Research Article

Full Title: Primary care providers’ and nurses’ knowledge, attitudes, and skills regarding latent TB

infection testing and treatment: A qualitative study from Rhode Island

I read carefully the paper with title and manuscript list above.

Beside that authors rise a thematic that is very import for healthcare institutions and hospitals, I consider that the proposal paper lacks in many aspects it orders to meet the scientific requirements for publication, especially in a journal as PLOS One is.

According to my opinion and the main concern is that the number of 21 primary care providers (PCP) including in this quality study is not sufficient, in a population of Rhode Island of more than 1 Mio, and a number of physicians of more than 2500. Also, I consider that the authors, should prepare one questionnaire that is uniform and all participants in the study to answer on it and not to be based just on the interview. I consider that on this approach the authors could get much more reliable data’s for their scientific study and based on these to have much more clear picture for knowledge, attitudes and skills of PCP regarding LTBI in Rhode Island.

In Introduction part there is many sentences that has not a reference; Line 62-65; Line 71-80; Line 84-86; ect…

The Results part has not been clarifying fully in all study aspect and moreover is not present appropriately. There is just one table and some interviews.

The Reference part is not uniform. I’m not sure for the style the authors selected and if this style has been applying to all references. See references Nb. 6,7,8,9,10,11,…

Also, the English written style in some sentences was not clear and understand, so my proposal is to be check by any professional scientific experience researchers for improve.

Based on all point mention above, I considered that this paper should be revise completely and after to be submitted once more.

Thank you and best regards.

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Reviewer #1: Yes: Ebrahim Aliafsari mamaghani

Reviewer #2: Yes: Prof Lufuno Makhado

Reviewer #3: No

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Attachments

Attachment

Submitted filename: Review and proposals_B.Neziri_27621.pdf

PONE-D-21-05814R1Primary care providers’ and nurses’ knowledge, attitudes, and skills regarding latent TB infection testing and treatment: A qualitative study from Rhode IslandPLOS ONE

Dear Dr. Szkwarko,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

Please submit your revised manuscript by Mar 07 2022 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

Please include the following items when submitting your revised manuscript:

• A rebuttal letter that responds to each point raised by the academic editor and reviewer(s). You should upload this letter as a separate file labeled 'Response to Reviewers'.
• A marked-up copy of your manuscript that highlights changes made to the original version. You should upload this as a separate file labeled 'Revised Manuscript with Track Changes'.
• An unmarked version of your revised paper without tracked changes. You should upload this as a separate file labeled 'Manuscript'.

If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter.

If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: https://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols. Additionally, PLOS ONE offers an option for publishing peer-reviewed Lab Protocol articles, which describe protocols hosted on protocols.io. Read more information on sharing protocols at https://plos.org/protocols?utm_medium=editorial-email&utm_source=authorletters&utm_campaign=protocols.

We look forward to receiving your revised manuscript.

Kind regards,

Hamidreza Karimi-Sari, MD

Academic Editor

PLOS ONE

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Partly

**********

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: No

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: No

**********

5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

**********

6. Review Comments to the Author

Reviewer #1: Thank you for your valuable work. The following can be effective in improving your work

The necessity of the work and the reason for using the qualitative method should be highlighted in the introduction.

- Explain the method of analysis and the type of qualitative method.

- Explain how to achieve saturation

- Explain how to ensure study rigor.

- Labeling the categories with a qualitative look

- At the beginning of the method, the clinical trial code is stated, but this study is descriptive and qualitative

PONE-D-21-05814R2Primary care providers’ and nurses’ knowledge, attitudes, and skills regarding latent TB infection testing and treatment: A qualitative study from Rhode IslandPLOS ONE

Dear Dr. Szkwarko,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process. Please carefully consider the peer-review comments in the next revision. Please submit your revised manuscript by Apr 14 2022 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

Please include the following items when submitting your revised manuscript:

• A rebuttal letter that responds to each point raised by the academic editor and reviewer(s). You should upload this letter as a separate file labeled 'Response to Reviewers'.
• A marked-up copy of your manuscript that highlights changes made to the original version. You should upload this as a separate file labeled 'Revised Manuscript with Track Changes'.
• An unmarked version of your revised paper without tracked changes. You should upload this as a separate file labeled 'Manuscript'.

If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter.

If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: https://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols. Additionally, PLOS ONE offers an option for publishing peer-reviewed Lab Protocol articles, which describe protocols hosted on protocols.io. Read more information on sharing protocols at https://plos.org/protocols?utm_medium=editorial-email&utm_source=authorletters&utm_campaign=protocols.

We look forward to receiving your revised manuscript.

Kind regards,

Hamidreza Karimi-Sari, MD

Academic Editor

PLOS ONE

Journal Requirements:

Please review your reference list to ensure that it is complete and correct. If you have cited papers that have been retracted, please include the rationale for doing so in the manuscript text, or remove these references and replace them with relevant current references. Any changes to the reference list should be mentioned in the rebuttal letter that accompanies your revised manuscript. If you need to cite a retracted article, indicate the article’s retracted status in the References list and also include a citation and full reference for the retraction notice.

Reviewers' comments:

Reviewer #1: For The necessity of the work and the reason for using the qualitative method should be highlighted in the introduction:

Your changes were not convincing to me. You can highlight the need to use this approach.

For Explain how to ensure study rigor:

Your changes were not convincing to me. Criteria as well as action for each criterion are not mentioned

For Labeling the categories with a qualitative look:

Your changes were not convincing to me.

Needs editing, especially in the case of spacing.

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While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool, https://pacev2.apexcovantage.com/. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email PLOS at figures@plos.org. Please note that Supporting Information files do not need this step.

Primary care providers’ and nurses’ knowledge, attitudes, and skills regarding latent TB infection testing and treatment: A qualitative study from Rhode Island

PONE-D-21-05814R3

Dear Dr. Szkwarko,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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Kind regards,

Hamidreza Karimi-Sari, MD

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments: