PONE-D-21-31674Inflammatory responses in SARS-CoV-2 associated Multisystem Inflammatory Syndrome and Kawasaki Disease in children: an observational studyPLOS ONE

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Additional Editor Comments:

Biesbroek et al. conducted an observational study on,” Inflammatory responses in SARS-CoV-2 associated Multisystem Inflammatory Syndrome and Kawasaki Disease in children”, in which they report that Multisystem Inflammatory Syndrome and Kawasaki Disease patients both displayed cytokine-associated hyper-inflammation with several high levels of drug-targetable cytokines. In my opinion this study can be improved by incorporating the following points:

1. The discussion can be improved further by discussing more about

2. When mentioning about “granzyme B (GMZB) detection did not significantly differ between groups”, the author should also state a p-value.

3. The strengths of the study need to be addressed along with how this study adds to the medical literature.

4. It can be mentioned how study focuses on a population that was not highlighted by previous authors, or whether this study demonstrates new results and how your study is superior to previous and other such studies.

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Inflammatory responses in SARS-CoV-2 associated Multisystem Inflammatory Syndrome and Kawasaki Disease in children: an observational study

PONE-D-21-31674R1

Dear Dr. Biesbroek,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

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Kind regards,

Tariq Jamal Siddiqi

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

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Reviewer #1: All comments have been addressed

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Reviewer #1: Yes

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Reviewer #1: Yes

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Reviewer #1: Yes

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Reviewer #1: Yes

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Reviewer #1: (No Response)

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Reviewer #1: No