PONE-D-21-33659Mortality and associated risk factors in patients hospitalized due to COVID-19 in a Peruvian reference hospital.PLOS ONE

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Reviewers' comments:

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Reviewer #1: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

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Reviewer #1: Yes

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Reviewer #1: No

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Reviewer #1: The authors aimed to determine risk factors for in-hospital mortality in patients with COVID-19 from a Peruvian national hospital.

The findings are interesting but there are no valid comments on cardiovascular disease (except hypertension) that are important factors for mortality in COVID-19 patients. I think in the discussion section the importance of cardiovascular disease must be deepened. For example cite and discuss the paper by Ielapi N. et al. Cardiovascular disease as a biomarker for an increased risk of COVID-19 infection and related poor prognosis. Biomark Med. 2020 Jun;14(9):713-716.

Overall considered discussion section is too superficial and must be better tailored on the main aspects of the paper.

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Reviewer #1: No

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Mortality and associated risk factors in patients hospitalized due to COVID-19 in a Peruvian reference hospital.

PONE-D-21-33659R1

Dear Dr. Soto,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

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Kind regards,

Prof. Raffaele Serra, M.D., Ph.D

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

amended manuscript is acceptable

Reviewers' comments: