PONE-D-21-34459Multi-omics Approaches for Comprehensive Analysis and Understanding of Immune Response in the Miniature Pig BreedPLOS ONE

Dear Dr. Park,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

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ACADEMIC EDITOR: As suggested by both the reviewers the MS in its current from is full of grammatical and syntactical errors. Authors are instructed to edit the MS for English language with the help of either a native English speaker or a reputed English editing service provider (in both cases certificate/proof has to be attached while uploading the revised MS). In addition, provide figures of acceptable quality as suggested by one of the reviewers.  

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We look forward to receiving your revised manuscript.

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Tushar Kanti Dutta, Ph.D.

Academic Editor

PLOS ONE

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(This work was supported by Korea Post-Genome Project (Project title: Deciphering the reference genome and the discovery of trait-associated genes in Nanchukmacdon and mini pigs). Project No. PJ013343 of the National Institute of Animal Science, Rural Development Administration, Republic of Korea. This study was supported by 2021 the RDA Fellowship Program of National Institute of Animal Science, Rural Development Administration, Republic of Korea. This funding helped in successfully performing all the sample analysis and provides the financial assistance to D.A.)

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(This funding helped in successfully performing all the sample analysis and provides the financial assistance to D.A Korea Post-Genome Project (Project No. PJ013343) and RDA Fellowship Program of National Institute of Animal Science, Rural Development Administration, Republic of Korea. No: The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.)

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Additional Editor Comments:

As suggested by both the reviewers the MS in its current from is full of grammatical and syntactical errors. Authors are instructed to edit the MS for English language with the help of either a native English speaker or a reputed English editing service provider (in both cases certificate/proof has to be attached while uploading the revised MS). In addition, provide figures of acceptable quality as suggested by one of the reviewers.

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

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3. Have the authors made all data underlying the findings in their manuscript fully available?

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Reviewer #1: Yes

Reviewer #2: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: No

Reviewer #2: No

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: General comments # 1: There are issues with the usage of English

General comments # 2: The text does not flow logically in the introduction, results and discussion, thereby greatly hampering the readability.

General comments # 3: The authors have not been careful and critical while drafting the manuscript. This is indicated by the spelling mistakes, undefined abbreviations and grammatical errors etc.

General comments # 4: All the figures should be replaced with good quality images

Reviewer #2: Article entitled, “ Multi-omics approaches for comprehensive analysis and understanding of immune response in the immature pig breed” is an unique study and is helpful for future approach for biomedical research. Therefore, I recommend this MS for publication after incorporating very minor corrections:

Line 44: Due to different size …..(the sentence needs correction). In my opinion this should be written as “ Due to different size and varied immune response, the test result is not mimicked in rodents which is otherwise possible in pig models. This has popularized pig for feasible use in biomedical research (6,7).

Line 49: Please delete the word dramatic

Line 50: “Furthermore, the immune system of minipig………preclinical trials.” Please make it two sentences.

Line 56: Why unnecessarily after genetic engineering “Hominidae” has been mentioned in bracket. Authors please justify.

The author is requested to correct the MS by an English speaking person specifically for Discussion and Result part.

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Reviewer #1: Yes: Sadeesh E.M

Reviewer #2: No

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Attachments

Attachment

Submitted filename: Comment.docx

Multi-omics Approaches for Comprehensive Analysis and Understanding of the Immune Response in the Miniature Pig Breed

PONE-D-21-34459R1

Dear Dr. Park,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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Kind regards,

Tushar Kanti Dutta, Ph.D.

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

I am provisionally accepting it to save time. However, at proof reading stage, kindly check figure legend details in page number 22. The information about S1 Fig and S2 Fig should go to supplementary file/data.

Reviewers' comments: