PONE-D-21-30389Seroprevalence of Antibodies against SARS-Cov-2 in the High Impacted Sub-district in Jakarta, IndonesiaPLOS ONE

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Reviewer #1: Yes

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: No

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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5. Review Comments to the Author

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Reviewer #1: This investigation uses serology testing to detect the antibodies against SARS-CoV-2 in the population of Tanjung Priok in Jakarta, Indonesia to estimate the seroprevalence and infection fatality rate (IFR) in the community. The results show that the prevalence of antibody against SARS-CoV-2 was 28.52%. The estimated IFR was 0.08%. The big difference between the estimated COVID-19 seroprevalence and the reported cumulative cases in Tanjung Priok shows significant under-reporting of COVID-19 cases in this community. As this study presented some interesting information on the estimated percentage of people infected by SARS-CoV-2 in Tanjung Priok sub-district of Jakarta, it may be published yet not in priority. This is because, in the current stage of the pandemic, after several waves of SARS-COV-2 virus breakout worldwide, understanding the actual prevalence of COVID-19 transmission in the community might not be strategically important in fighting the COVID-19 pandemic when most of the COVID-19 cases are asymptomatic or mild. Contrary to the authors suggestion of putting more efforts to amplify epidemiological surveillance by the provincial and local governments, more efforts and resources should be reserved for the care and treatment of the severe cases of COVID-19 patients to save lives.

Reviewer #2: In the current research article entitled " Seroprevalence of Antibodies against 1 SARS-Cov-2 in the High Impacted Sub-district in Jakarta, Indonesia", by Herlinda et al., have studied/surveyed estimate the seroprevalence and infection fatality rate (IFR) in Tanjung Priok, the hardest-hit sub-district by the COVID-19 in Jakarta, Indonesia. Authors conducted venous blood sampling to 3,196 individuals in Tanjung Priok between Nov 23, 2020, and Feb 19, 2021. They found that, under-reporting is an issue between the estimated COVID-19 seroprevalence and the reported cumulative cases in Tanjung Priok. This article addresses a research topic of great interest, which is under intense investigation in the past 2 years and the manuscript is generally well-written. However, this reviewer has certain suggestions that would help produce a more comprehensive overview of the topic:

Suggestions:

1. The authors may additionally provide one Figure as summary, challenges, or prospect of the present study.

2. The authors should cross-check all abbreviations in the manuscript. Initially, define in full name followed by abbreviation.

3. The English of manuscript can be polished (minor).

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Seroprevalence of Antibodies against SARS-Cov-2 in the High Impacted Sub-district in Jakarta, Indonesia

PONE-D-21-30389R1

Dear Dr. Bella,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

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Kind regards,

Sanjay Kumar Singh Patel, Ph.D.

Academic Editor

PLOS ONE