PONE-D-21-27488Effect of obstructive sleep apnea on cerebrovascular compliance and cerebral small vessel diseasePLOS ONE

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Additional Editor Comments:

Well written study. Reviewers suggest minor revisions

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Reviewers' comments:

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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5. Review Comments to the Author

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Reviewer #1: Interesting paper, minor corrections to improve the quality:

Introduction

-line 55, Subcortical ischemic vascular dementia (SIVD) is very common among older people, but has no approved treatment. A recent randomized study has shown that remote ischemic conditioning (RIC) reduces the recurrence of ischemic stroke and is an effective therapy for patients with SIVD. please cite doi: 10.1186/s12883-019-1435-y.

- line 60, elderly patients are known to have an increased risk of OSAS, with a prevalence of more severe forms after 65 than younger patients. The same severity of obstructive sleep apnea has also been shown to be related to olfactory disorders in the patient with obstructive sleep apnea, the origin of which could be attributed to disorders of the central nervous system. please cite doi:10.1007/s00405-020-06316-w.

line 70, please cite doi:10.14639/0392-100X-895

Methods and results well structured and clearly expressed

Discussion

line 311, also surgical approaches demonstrated improvement of obstructive sleep apnea syndrome (OSAS) and changes in high sensitivity C-reactive protein (hs-CRP) concentrations have been reported after transfer pharyngoplasty (RP), an elevated variant of uvulopalatopharyngoplasty, reducing cardiovascular risk in subjects with obstructive sleep apnea.

please cite doi:10.1177/0194599810395104 and doi:10.1007/s00405-020-05883-2

Reviewer #2: The paper examined an interesting topic. I support its approval suggesting some minor corrections to improve the quality:

Introduction:

Line 60: Reported incidence of OSA is from 5.6% to 60% in people over 65 (cite doi: 10.3390/ijerph17031120) while SVD presents an increased one from 6% at age 60 to 28% at age 80 (cite doi: 10.3390/ijerph17031120).

Line 70: The endothelial dysfunction, may be related to the consequent generation of reactive oxygen species (ROS) and pro-inflammatory molecules, resulting in microvascular damage in OSA patients (cite doi.org/10.3390/jcm10020277).

Methods: clearly expressed and structured

Results: well written and exhaustive.

Discussion:

Line 295: A recent meta-analysis reported that moderate to severe OSA is positively associated with WMH and SBI but not CMBs or PVS (cite doi: 10.1093/sleep/zsz264).

In all paper put the dots after the brackets.

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Reviewer #1: No

Reviewer #2: No

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Effect of obstructive sleep apnea on cerebrovascular compliance and cerebral small vessel disease

PONE-D-21-27488R1

Dear Dr. Lee,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

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Kind regards,

Academic Editor

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Additional Editor Comments (optional):

interesting and well-structured paper, I find it useful to clarify some aspects related to the complications of OSA. the authors improved the text in accordance with the reviewers' suggestions. Well done. Compliments

Reviewers' comments:

-