PONE-D-21-19050

Effects of cannabis ingestion on endometriosis-associated pelvic pain and related symptoms.

PLOS ONE

Dear Dr. Sinclair,

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PLOS ONE

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Reviewers' comments:

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Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

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Reviewer #1: Yes

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Reviewer #1: Yes

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5. Review Comments to the Author

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Reviewer #1: The study is well thought out and properly written. In the introduction you should add that endometriosis not only affects women of childbearing age, but also postmenopausal (cites "Retroperitoneal endometriosis in postmenopausal woman causing deep vein thrombosis: case report and review of the literature, Ianieri MM, Clin Exp Obstet Gynecol. 2017; 44 (1): 148-150)

The materials and methods are clear as well as the results. The discussion should also be improved by talking about the potential hypertonus pelvic muscles of patients with endometriosis (cite DOI 10.1002 / uog.18924, Mabrouk M 2018) and the potential effect of cannabis at therapeutic dosage.

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Reviewer #1: No

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Effects of cannabis ingestion on endometriosis-associated pelvic pain and related symptoms.

PONE-D-21-19050R1

Dear Dr. Sinclair,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

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Kind regards,

Diego Raimondo

Academic Editor

PLOS ONE