The accuracy of diagnostic indicators for coeliac disease: a systematic review and meta-analysis

PONE-D-21-25925

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Reviewer #2: Yes

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Reviewer #2: Yes

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Reviewer #1: I was very happy with the responses of the authors. I am looking forward to seeing this paper online (and the health economic follow-up).

It is interesting that your update produced a significant association with liver disease. This coincides with the publication of another manuscript by Glimberg/Haggard et al, that found a 3.5% prevalence of celiac disease among individuals with autoimmune hepatitis, further supporting your findings.

https://pubmed.ncbi.nlm.nih.gov/34219350/

I also what to congratulation Penny Whiting for her earlier landmark paper on the QUADAS tool in BMC research methodology 18 years ago!

https://bmcmedresmethodol.biomedcentral.com/articles/10.1186/1471-2288-3-25

Reviewer #2: Although the term "diagnostic indicators" it is fully defined in the methods part, the use of the term already in the title is little bit confusing/ misleading as in the current "celiac disease language field" this usually refer to laboratory testing and diagnostic markers. No need the Title to be changed, but indeed, when reading the title I expected it will all be about biological and immunological indicators.

The paper is otherwise very interesting and well conducted; the results actually provide "scientific back-up" of an already assumed fact from clinical practice: the low predictive ability of the symptoms to detect CD.

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Reviewer #1: No

Reviewer #2: No